Results 11 to 20 of about 4,122 (198)

Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas. [PDF]

PLoS ONE, 2012
Activating c-KIT mutations (exons 11 and 17) are found in 10-40% of testicular seminomas, the majority being missense point mutations (codon 816). Malignant ovarian dysgerminomas represent ~3% of all ovarian cancers in Western countries, resembling ...
Remko Hersmus, Hans Stoop, Gert Jan van de Geijn, Ronak Eini, Katharina Biermann, J Wolter Oosterhuis, Catharina Dhooge, Dominik T Schneider, Isabelle C Meijssen, Winand N M Dinjens, Hendrikus Jan Dubbink, Stenvert L S Drop, Leendert H J Looijenga   +12 more
doaj   +9 more sources

Advanced-Stage Gonadal Dysgerminoma in a Patient With a Previous Diagnosis of Familial Swyer Syndrome: A Very Rare Genetic Entity. [PDF]

Case Rep Med
Introduction Swyer syndrome is a genetic abnormality characterized by a 46,XY karyotype in a phenotypically female individual. Affected individuals typically have average or tall stature, unambiguous genitalia at birth, the presence of Müllerian structures, and bilateral streak gonads.
Oğlak SC, Söğütçü N, Akgöl S, Adıgüzel Ö, Ateş Eminoğlu HE, Güzel G, Balcı V, Acar E, Acar A, Bozan F.   +9 more
europepmc   +2 more sources

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T-Cell Exhaustion in Dysgerminoma. [PDF]

Cancer Sci
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Nakashima M, Iwasaki T, Katayama Y, Shimo M, Takigawa K, Shimada N, Matsushita M, Kuwamoto S, Sato S, Toya M, Miyawaki K, Akashi K, Kato K, Oda Y.   +13 more
europepmc   +2 more sources

Imaging Findings in Dysgerminoma in a Case of 46 XY, Complete Gonadal Dysgenesis (Swyer syndrome) [PDF]

Journal of Clinical and Diagnostic Research, 2016
A 46 XY pure gonadal dysgenesis also known as Swyer syndrome. These patients are phenotypic females with normal female external genitalia and absent testicular tissue.
Pratiksha Yadav, Sanjay Khaladkar, Aditi Gujrati   +2 more
doaj   +1 more source

Intracranial Dysgerminomas [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1976
SUMMARY:We have reported three cases of intracranial dysgerminoma. The origin of these tumors has been controversial for a long time. It is now accepted that they develop from germ cells. The diagnosis is often difficult to confirm because of the variety of signs.
G, Leblanc, J, Francoeur, M, Copty, C, Contreras, F, Gagne   +4 more
openaire   +2 more sources

Germ cell and other tumors in individuals with differences in sex development. [PDF]

CA Cancer J Clin
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Witchel SF, Reyes-Múgica M.
europepmc   +2 more sources

An Incidental Finding of Bilateral Dysgerminoma During Cesarean Section: Dilemmas in Management [PDF]

Journal of Clinical and Diagnostic Research, 2016
Dysgerminoma is an uncommon malignant tumour arising from germ cells of ovary. It occurs mostly in the reproductive age group. Its association with pregnancy is rare. Its management remains a challenge especially in an unsuspected case.
Mamta Gupta, Rita Jindal, Vandana Saini
doaj   +1 more source

An aggressive systemic mastocytosis preceded by ovarian dysgerminoma

BMC Cancer, 2020
Background Aggressive systemic mastocytosis (ASM) is a rare malignant disease characterized by disordered mast cell accumulation in various organs. We here describe a female ASM patient with a previous history of ovarian dysgerminoma.
Makiko Tsutsumi, Hiroki Miura, Hidehito Inagaki, Yasuko Shinkai, Asuka Kato, Takema Kato, Susumu Hamada-Tsutsumi, Makito Tanaka, Kazuko Kudo, Tetsushi Yoshikawa, Hiroki Kurahashi   +10 more
doaj   +1 more source

Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty

Case Reports in Pathology, 2021
Dysgerminoma is a malignant ovarian germ cell tumor, and unlike sex-cord stromal tumors, endocrine manifestation is considered rare. Here, we report the first case of dysgerminoma presenting precocious puberty.
Shunsuke Nagase, Kanako Ogura, Karin Ashizawa, Nana Nakazawa-Tanaka, Masahiko Urao, Masaharu Fukunaga, Yuto Yamazaki, Hironobu Sasano, Toshiharu Matsumoto   +8 more
doaj   +1 more source

Clinical and morphological features of ovarian pure dysgerminoma: a report of a 14 years old girl [PDF]

Archive of Oncology, 2002
Dysgerminoma is best known as the ovarian counterpart of seminoma of the testis Relatively uncommon tumors, dysgerminomas account for less than 2% of all ovarian cancer.
Pop-Trajković Zoran, Veljković Milena, Radović Miodrag, Katić Vuka V., Petrović Aleksandar S., Lilić Vekoslav   +5 more
doaj   +1 more source