Results 181 to 190 of about 16,889 (275)

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone

open access: yesClinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen   +3 more
wiley   +1 more source

Red‐light flashing pens and seizures in children

open access: yesDevelopmental Medicine &Child Neurology, Volume 68, Issue 6, Page 864-868, June 2026.
Guidelines exist to limit seizure‐provoking visual stimuli. However, existing recommendations are not universally applied, and poorly regulated flickering lights are easily encountered in consumer products. Two girls experienced prolonged absence seizures triggered by a red‐light flickering pen.
Simone Gasparini   +4 more
wiley   +1 more source

Freezing of Gait in Parkinson's Disease: A Heterogeneous Phenomenon Across Assessment Tools

open access: yesEuropean Journal of Neuroscience, Volume 63, Issue 11, June 2026.
Freezing of gait in Parkinson's disease is a heterogeneous, context‐ and tool‐dependent phenomenon that may emerge in early disease. Capturing freezing requires multimethod assessment, and interpretation of freezing‐related outcomes should take into account disease severity.
Jacques Duysens   +1 more
wiley   +1 more source

Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia. [PDF]

open access: yesNeuron
Shen W   +11 more
europepmc   +1 more source

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