Results 51 to 60 of about 16,889 (275)

Pathophysiology of Drug-Induced Dyskinesias

, 2011
Christopher A. Lieu1,2, Vikram Shivkumar1, Timothy P. Gilmour1,2, Kala Venkiteswaran1,2, Mark J. Nolt1,3, Milind Deogaonkar4 and Thyagarajan Subramanian1,2 1Department of Neurology, The Pennsylvania State University College of Medicine and M.S. Hershey Medical Center, Hershey, Pennsylvania 2Department of Neural & Behavioral Sciences, The Pennsylvania ...
Christopher A., Vikram Shivkumar, Timothy P., Kala Venkiteswaran, Mark J., Milind Deogaonkar, Thyagarajan Subramani   +6 more
openaire   +2 more sources

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

Frontiers in Aging Neuroscience, 2020
Levodopa (L-DOPA) treatment is the main gold-standard therapy for Parkinson disease (PD). Besides good antiparkinsonian effects, prolonged use of this drug is associated to the development of involuntary movements known as L-DOPA-induced dyskinesia (LID).
Valeria Calabrese, Valeria Calabrese, Anna Di Maio, Gioia Marino, Gioia Marino, Antonella Cardinale, Antonella Cardinale, Giuseppina Natale, Giuseppina Natale, Arianna De Rosa, Federica Campanelli, Federica Campanelli, Maria Mancini, Francesco Napolitano, Francesco Napolitano, Luigi Avallone, Paolo Calabresi, Paolo Calabresi, Alessandro Usiello, Alessandro Usiello, Veronica Ghiglieri, Veronica Ghiglieri, Barbara Picconi, Barbara Picconi   +23 more
doaj   +1 more source

Electroconvulsive Therapy for Severe Refractory Tardive Dystonia Without Active Depression: A Case Report. [PDF]

Neuropsychopharmacol Rep
Electroconvulsive therapy produced clinically meaningful improvement in severe refractory tardive dystonia without active depression, including recovery of independent ambulation. However, symptom recurrence after discontinuation highlights the potential need for continuation or maintenance strategies.
Asahi T, Kawamata Y, Sugawara N, Maehara R, Yasui-Furukori N.   +4 more
europepmc   +2 more sources

Frequency‐ and Network‐Specific Changes in Functional Connectivity Reflect Pathophysiological Mechanisms across Parkinson's Disease Stages

Annals of Neurology, EarlyView.
Objective Parkinson's disease (PD) is increasingly conceptualized as a disorder of large‐scale brain networks, yet whether and how frequency‐specific functional connectivity reorganizes across stages remains poorly understood. In this study, we used high‐density electroencephalography (EEG) to characterize cortico‐cortical functional connectivity ...
Matteo Conti, Valentina D'Onofrio, Luca Lorenzon, Laura Ludovica Grassi, Davide Mascioli, Valerio Ferrari, Clara Simonetta, Sofia Pavan, Francesca Di Giuliano, Mariangela Pierantozzi, Tommaso Schirinzi, Diego Centonze, Maurizio Corbetta, Angelo Antonini, Alessandro Stefani, Andrea Guerra   +15 more
wiley   +1 more source

Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist–induced orofacial dyskinesia

JCI Insight, 2021
Antipsychotics often cause tardive dyskinesia, an adverse symptom of involuntary hyperkinetic movements. Analysis of the US Food and Drug Administration Adverse Event Reporting System and JMDC insurance claims revealed that acetaminophen prevented the ...
Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko   +13 more
doaj   +1 more source

Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias: a retrospective case-control study

Neural Regeneration Research, 2021
Growing evidence has highlighted that angiotensin-converting enzyme (ACE)-inhibitors (ACEi)/AT1 receptor blockers (ARBs) may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway, thus affecting ...
Elena Contaldi, Luca Magistrelli, Anna V Milner, Marco Cosentino, Franca Marino, Cristoforo Comi   +5 more
doaj   +1 more source

Fluoxetine Induced Dyskinesia

, 1994
A case of fluoxetine induced dyskinesia in an elderly woman with previous use of low dose haloperidol is described. In contrast to neuroleptic induced tardive dyskinesia it was characterised by a rapid onset after commencing fluoxetine and rapid ...
B. Workman, Michael McCausland, H. Flamer, Alastair Mander, Nicholas Christophidis   +4 more
core   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

A survey of the tardive dyskinesia induced by antipsychotic drugs in patients with schizophrenia. [PDF]

Iranian Journal of Psychiatry, 2010
Objective: Tardive Dyskinesia (TD), is one of the important problems of the patients with schizophrenia. The emergence of these side effects depends on so many factors such as the patients' age and the duration of antipsychotic treatment.
Sahel Hemmati, Ali Nazeri Astaneh, Farin Solemani, Roshanak Vameghi, Firouzeh Sajedi, Naser Tabibi   +5 more
doaj   +1 more source