Results 141 to 150 of about 249,813 (313)

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Dyslipidemia and Pharmacist's Role

, 2019
Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally. It commonly coexists with other clinical conditions such as dyslipidemia and hypertension. Based on the manifestations a patient is experiencing, therapies may be added
Ahmed Awaisu, Yaw Owusu, Sowndramalingam Sankaralingam, Oraib Abdallah, Al-Ismail, Muna, Awaisu, Ahmed, Sankaralingam, Sowndramalingam, Abdallah, Oraib, Muna Al-Ismail, Owusu, Yaw   +9 more
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Diabetes, metabolic syndrome and dyslipidemia in people living with HIV in Africa: re-emerging challenges not to be forgotten

, 2017
Nazik Elmalaika Husain,1 Sufian K Noor,2 Wadie M Elmadhoun,3 Ahmed O Almobarak,4 Heitham Awadalla,5 Clare L Woodward,6 Dushyant Mital,6 Mohamed H Ahmed7 1Department of Pathology, Faculty of Medicine and Health Sciences, Omdurman Islamic University ...
Awadalla H, Husain NE, Woodward CL, Noor SK, Elmadhoun WM, Ahmed MH, Almobarak AO, Mital D   +7 more
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Sex Differences in Social, Health, and Lifestyle Characteristics Associated With Binge‐Eating Behaviors: Results From a French National Random Population‐Based Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To explore sex differences in social, health and lifestyle characteristics associated with binge‐eating behaviors in a large population‐based study. Method This study included 84,995 participants (women 52.1%) aged ≥ 15 years from the French national random population‐based EpiCov cohort.
Junko Kose, Nathalie Godart, Anne Pastorello, Caroline Huas, Alexandra Rouquette, EpiCov Study Group, Josiane Warszawski, Nathalie Bajos, Guillaume Bagein, François Beck, Emilie Counil, Florence Jusot, Nathalie Lydié, Claude Martin, Laurence Meyer, Philippe Raynaud, Alexandra Rouquette, Ariane Pailhé, Delphine Rahib, Patrick Sillard, Rémy Slama, Alexis Spire   +21 more
wiley   +1 more source

Machine learning‐based prediction of elevated N terminal pro brain natriuretic peptide among US general population

ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori, Shingo Fukuma, Kyohei Yamaji, Atsushi Mizuno, Naoki Kondo, Kosuke Inoue   +5 more
wiley   +1 more source

Glucose and Loss of Control Eating: Evidence From Naturalistic Assessment After Roux‐en‐Y Gastric Bypass

European Eating Disorders Review, EarlyView.
ABSTRACT Objective While loss of control (LOC) eating is associated with poor outcomes following metabolic and bariatric surgery (MBS), the mechanisms driving it are less understood. This study used momentary, naturalistic data to examine glucose as a biological correlate of LOC eating after Roux‐en‐Y gastric bypass (RYGB).
Gail A. Kerver, Kristine J. Steffen, Debra L. Safer, Glen Forester, David B. Sarwer, Stephen A. Wonderlich, Scott G. Engel   +6 more
wiley   +1 more source

Patterns and Factors Associated with Dyslipidemia Among Patients with Diabetes Mellitus Attending Hoima Regional Referral Hospital, Uganda

Abishir Mohamud Hirsi, Awil Abdukadir Abdi, Alina Peris, Amandua Jacinto, Propser Muhammad, Ibrahim Ahmed Nur, Muktar Hassan Mohamud, Mustafa Hussein, Abdi Qaws, Mohamed Jayte Department of Internal Medicine, Faculty of Clinical Medicine and Dentistry ...
Nur IA, Mohamud MH, Jayte M, Hirsi AM, Muhammad P, Jacinto A, Hussein M, Qaws A, Abdi AA, Peris A   +9 more
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Prevalence of Dyslipidemia and Related Risk Factors Among Adults in Armenia

, 2017
This study provides insight into the previously unreported prevalence of dyslipidemia in a region with high CVD ...
Hripsime Z. Wright, MD, MPH; Ketevan Amirkhanashvili MS2; Natalie Channel MS2; Marine G. Hovhannisyan, MD, MPH
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