Results 91 to 100 of about 16,949 (278)

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Differential lipid metabolism in monocytes and macrophages: influence of cholesterol loading[S]

Journal of Lipid Research, 2016
The influence of the hypercholesterolemia associated with atherosclerosis on monocytes is poorly understood. Monocytes are exposed to high concentrations of lipids, particularly cholesterol and lysophosphatidylcholine (lyso-PC).
Irene Fernandez-Ruiz, Patrycja Puchalska, Chandrakala Aluganti Narasimhulu, Bhaswati Sengupta, Sampath Parthasarathy   +4 more
doaj   +1 more source

Dietary Intake as a Link between Obesity, Systemic Inflammation, and the Assumption of Multiple Cardiovascular and Antidiabetic Drugs in Renal Transplant Recipients. [PDF]

, 2013
We evaluated dietary intake and nutritional-inflammation status in ninety-six renal transplant recipients, 7.2±5.0 years after transplantation. Patients were classified as normoweight (NW), overweight (OW), and obese (OB), if their body mass index was ...
APICELLA, LUCA, CATALDI, MAURO, FEDERICO, STEFANO, Germanò R, GUIDA, BRUNA, Maresca ID, MEMOLI, ANDREA, MEMOLI, BRUNO, Nastasi AM, SABBATINI, MASSIMO, TRIO, ROSSELLA   +10 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism [PDF]

, 2009
Analysis of variants in three genes encoding oxysterol-binding protein (OSBP) homologues (OSBPL2, OSBPL9, OSBPL10) in Finnish families with familial low high-density lipoprotein (HDL) levels (N = 426) or familial combined hyperlipidemia (N = 684 ...
Julia Perttilä, Krista Merikanto, Jussi Naukkarinen, Ida Surakka, Nicolas W. Martin, Kimmo Tanhuanpää, Vinciane Grimard, Marja-Riitta Taskinen, Christoph Thiele, Veikko Salomaa, Antti Jula, Markus Perola, Ismo Virtanen, Leena Peltonen, Vesa M. Olkkonen, GD Fairn, D Yan, CJ Jaworski, M Lehto, RJ Perry, PY Wang, D Yan, D Yan, D Yan, M Ngo, C Wang, JJ Genest Jr, JL Goldstein, EA Nikkilä, O Stein, P Pajukanta, A Soro, R Haperen van, M Johansson, S Kathiresan, S Kathiresan, CJ Willer, JC Cohen, MA Welte, JF Presley, K Hirschberg, D Toomre, C Vedrenne, RS Cohen, MA Welte, RM Rios   +45 more
core   +1 more source

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

AGING MEDICINE, EarlyView.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long Feng   +15 more
wiley   +1 more source

Análise do perfil lipídico em escolares Lipid profile analysis in school children

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: A aterosclerose coronariana (DAC) é a maior causa mortis do mundo, segundo a Organização Mundial de Saúde. O estudo INTERHEART mostrou que a dislipidemia é um dos maiores fatores de risco independente para o IAM.
Carlos Scherr, Cyntia Karla Magalhães, Waldir Malheiros   +2 more
doaj   +1 more source

A Primer on Quality Assurance and Performance Improvement for Interprofessional Chronic Kidney Disease Care: A Path to Joint Commission Certification. [PDF]

, 2019
Interprofessional care for chronic kidney disease facilitates the delivery of high quality, comprehensive care to a complex, at-risk population. Interprofessional care is resource intensive and requires a value proposition. Joint Commission certification
Awdishu, Linda, Moore, Teri, Morrison, Michelle, Trzebinska, Danuta, Turner, Christy   +4 more
core   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Lipoprotein(a) apheresis restores coronary microcirculation in refractory angina

Revista Portuguesa de Cardiologia, 2022
Francesco Sbrana, Beatrice Dal Pino, Giovanni Donato Aquaro, Federico Bigazzi, Giuseppe Vergaro, Tiziana Sampietro   +5 more
doaj   +1 more source