Results 51 to 60 of about 101,444 (326)
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Metformin: From diabetes to cancer to prolongation of life
Pharmacological ResearchThe metformin molecule dates back to over a century, but its clinical use started in the ‘50s. Since then, its use in diabetics has grown constantly, with over 150 million users today. The therapeutic profile also expanded, with improved understanding of
Cesare R. Sirtori +2 more
doaj +1 more source
The Contribution of GWAS Loci in Familial Dyslipidemias
PLoS Genetics, 2016 Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels with over five-fold risk of coronary heart disease.
P. Ripatti +16 more
semanticscholar +1 more source
Trends and Regional Differences in the Prevalence of Dyslipidemia before and after the Great East Japan Earthquake: A Population-Based 10-Year Study Using the National Database in Japan [PDF]
, 2022 Shigetaka Nakajima +5 more
openalex +1 more source
Advanced Materials, EarlyView.The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim +12 more
wiley +1 more source
Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases
Cancer Medicine, 2018 We examined the risk of prostate cancer in the Korean population stratified on the basis of age group and risk based on metabolic diseases, using National Health Insurance System (NHIS) data.
Jin Bong Choi +4 more
doaj +1 more source
Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations [PDF]
The Korean Journal of Internal MedicinePatients with chronic kidney disease (CKD) have a significantly increased risk of developing cardiovascular disease (CVD), making dyslipidemia management a critical component of cardiovascular risk reduction in this population.
Ji Yoon Kim, Suk Min Chung, Nam Hoon Kim
doaj +1 more source
Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
Prevalence of Dyslipidemias in Three Regions in Venezuela: The VEMSOLS Study Results
Arquivos Brasileiros de Cardiologia, 2018 Background The prevalence of dyslipidemia in multiple regions of Venezuela is unknown. The Venezuelan Metabolic Syndrome, Obesity and Lifestyle Study (VEMSOLS) was undertaken to evaluate cardiometabolic risk factors in Venezuela.
J. González-Rivas +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu +13 more
wiley +1 more source