Results 141 to 150 of about 51,850 (252)

Safety, Tolerability, and Pharmacokinetics of Oral Camlipixant: A Randomized First‐In‐Human Study Using Single and Multiple Ascending Doses

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Camlipixant is a highly selective P2X3 receptor antagonist with demonstrated efficacy in pre‐clinical models of evoked cough. We report the safety, tolerability, and pharmacokinetics of camlipixant in healthy participants. This Phase 1, double‐blind, randomized study evaluated single ascending doses (SAD; 50/100/200/400/800/1200 mg) and ...
Nathalie Chauret   +6 more
wiley   +1 more source

Efficacy and Tolerability of Tegoprazan Compared to Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

open access: yesJGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aim Tegoprazan, a potassium‐competitive acid blocker, is an acid‐suppressing medication under review as a potential alternative treatment in cases of erosive esophagitis. This systematic review and meta‐analysis assesses the efficacy and tolerability of tegoprazan compared to proton pump inhibitors, the current standard of care. Methods Pubmed,
Youssef Diab   +6 more
wiley   +1 more source

Gastric cancer secondary prevention in dyspeptic patients. [PDF]

open access: yesGastric Cancer
Fiorini G   +15 more
europepmc   +1 more source

Golgi Protein 73 and Laminin‐γ2 Monomer‐Based Score for the Diagnosis of Advanced Liver Fibrosis in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesJGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Background This study evaluated the diagnostic performance of Golgi protein 73 (GP73), laminin‐γ2 monomer (LG2m), and the GLAS score in detecting advanced fibrosis in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). Methods This study included patients with MASLD who underwent liver biopsy.
Xin‐Tong Ng   +7 more
wiley   +1 more source

European Society for Paediatric Gastroenterology, Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition guidelines for treatment of functional constipation in children aged 0–18 years

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 2, Page 335-366, August 2026.
Abstract Objectives Functional constipation (FC) is common in childhood, significantly impacting quality of life. Since the 2014 international guideline, new evidence has been published, and methods on making guidelines have developed. This treatment guideline for FC in children aged 0–18 years is a collaborative effort of the European and North ...
Morris Gordon   +17 more
wiley   +1 more source

S1 Guideline of the German Society for Neurogastroenterology and Motility (DGNM) on Functional Dyspepsia (FD), a Disorder of Gut-Brain Interaction (DGBI) [English Language Edition]. [PDF]

open access: yesGastroenterol Res Pract
Storr M   +11 more
europepmc   +1 more source

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