Results 51 to 60 of about 387,749 (347)

In vivo direct lentiviral gene therapy improves disease pathology in a mucopolysaccharidosis IVA murine model

Molecular Therapy: Methods & Clinical Development
Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder that causes the accumulation of keratan sulfate (KS) and chondroitin-6-sulfate in bone and cartilage.
Betul Celik, Estera Rintz, Shaukat Khan, Andrés Felipe Leal, Fnu Nidhi, Shunji Tomatsu   +5 more
doaj   +1 more source

Proteomics Research on Gastric Intraepithelial Neoplasia

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the expression of differential proteins in the typical process of gastric intraepithelial neoplasia including normal gastric antrum mucosa, reactive hyperplasia, low-grade intraepithelial neoplasia, high-grade intraepithelial ...
GUAN Xiaoying, WANG Furong
doaj   +1 more source

Intramucosal Poorly Differentiated Adenocarcinomas Detected in a Patient with Long-Standing Ulcerative Colitis

Case Reports in Oncology, 2020
We report a case of long-standing ulcerative colitis with intramucosal well- and poorly differentiated adenocarcinomas detected over a 6-month duration.
Junichi Zaitsu, Kazuya Kuraoka, Akira Ishikawa, Hideki Yamamoto, Daiki Taniyama, Akihisa Saito, Toshio Kuwai, Yosuke Shimizu, Hirotaka Tashiro, Kiyomi Taniyama   +9 more
doaj   +1 more source

Comparative study on the efficacy of tissue autofluorescence (visually enhanced lesion scope) and toluidine blue as a screening method in oral potentially malignant and malignant lesions

Journal of Medical Sciences, 2017
Objective and Study Design: Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. Hence, screening of such lesions and their early detection could improve prognosis.
Hasan Ali Adil, Monal Yuwanati, Aarti Singh, Suvarna Sawant, Hemant R Umarji   +4 more
doaj   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Challenges in the implementation of a high-resolution anoscopy clinic for people with HIV in an oncologic center in Mexico City

AIDS Research and Therapy
Background Anal cancer incidence is increased in people with HIV (PWH), up to 60 times higher in men who have sex with men, and almost 15 times higher among women with HIV.
Patricia Volkow, Salim Barquet-Muñoz, Naomi Jay, Maria-José Mendoza, Paulina Moctezuma, Mariel Morales-Aguirre, Delia Pérez-Montiel, Víctor Larraga, Alexandra Martin-Onraet   +8 more
doaj   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source

Clinical and radiographic evaluation of subsidence in two femoral stem models for a total hip replacement in dogs

Veterinární Medicína, 2022
Canine cementless total hip arthroplasty (THA) is a successful technique for the management of hip arthrosis; however, serious potential complications, such as femoral fractures and subsidence of the femoral stem, can occur. To evaluate the effect of two
Bruno Watanabe Minto, Lucia Maria Izique Diogo, Caroline Ribeiro de Andrade, Wanderley Severo Dos Santos Junior, Luis Guilherme de Faria, Fernando Yoiti Kitamura Kawamoto, Tiago Carmagnani Prada, Luis Gustavo Gosuen Goncalves Dias   +7 more
doaj   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Assessment of apoptotic index in various grades of oral epithelial dysplasia: A cross-sectional study

Indian Journal of Pathology and Microbiology, 2020
Context: Oral cancer is a major health problem worldwide. In cancer, the equilibrium between cell proliferation and apoptosis is disturbed. The defect in the apoptotic pathway allows cells to proliferate with genetic abnormalities.
Rasika B Pawar, Sangeeta J Palaskar, Shravani S Kalavankar   +2 more
doaj   +1 more source