Results 71 to 80 of about 278,748 (316)

Evaluation of p53 protein expression in Barrett esophagus

Indian Journal of Pathology and Microbiology, 2018
Background: Loss of heterozygosity of p53 along with aneuploidy is deemed to be the early molecular steps in Barrett metaplasia-dysplasia-adenocarcinoma sequence.
Mahathi Krothapalli, Jyoti Ramnath Kini, Hema Kini, Kausalya Kumari Sahu, Suresh Shenoy, Sandeep Gopal Krishna, B V Tantry   +6 more
doaj   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

The skeletal dysplasias [PDF]

Genetics in Medicine, 2010
The skeletal dysplasias (osteochondrodysplasias) are a heterogeneous group of more than 350 disorders frequently associated with orthopedic complications and varying degrees of dwarfism or short stature. These disorders are diagnosed based on radiographic, clinical, and molecular criteria.
Deborah, Krakow, David L, Rimoin
openaire   +2 more sources

Relationship of acetabular dysplasia in females with osteoarthritis of the hip to the distance between both anterior superior iliac spines

, 2014
Background: Acetabular dysplasia (AD) is the main cause of hip osteoarthritis in Japan. A simple method to evaluate acetabular dysplasia would be helpful for early treatment or prevention of hip osteoarthritis.
Itoman, Moritoshi, Yamada, Harumoto, Takatori, Yoshio, Ito, Hiroshi, Owan, Ichiro, Ohashi, Hirotsugu, Yasunaga, Yuji, Mori, Satoshi, Jingushi, Seiya, Hirota, Yoshio, Ohfuji, Satoko, Sofue, Muroto, Yamaguchi, Kazumasa, Hamada, Yoshiki, Okano, Kunihiko, Shindo, Hiroyuki   +15 more
core   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Difference between clinical and ultrasound screening of developmental hip abnormalities in neonatal period [PDF]

Medicinski Glasnik, 2007
The development disorder of the hip (DDH) is the most common anomaly of the locomotors’ system and a permanently present problem in pediatric and orthopedic practice, because of its numerous consequences.
A. Brčić
doaj  

Dentin dysplasia type II: An exclusive report of two cases in siblings

Journal of Indian Academy of Oral Medicine and Radiology, 2017
Dentin dysplasia is a rare autosomal dominant disorder affecting dentin and resulting in early loss of teeth. Although dentin dysplasia type I is reported to have an incidence of 1 in 100,000, dentin dysplasia type II is considered to be an extremely ...
Deepak Daryani, Gopakumar R Nair, Giridhar Naidu   +2 more
doaj   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Evaluation and Clinicopathological Correlation of ALDH1 in Colorectal Adenoma with Low-/High-Grade Dysplasia and Carcinoma.

South Asian Journal of Cancer
Colorectal carcinoma (CRC) stands as one of the most prevalent malignant neoplasms, carrying significant morbidity and mortality implications. Within colorectal carcinogenesis, cancer stem cells are recognized as key contributors, infusing tumors with ...
Himanshi Bhanu, Ruchi Mittal, Urmila Senapati   +2 more
doaj   +1 more source

Proteomics Research on Gastric Intraepithelial Neoplasia

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the expression of differential proteins in the typical process of gastric intraepithelial neoplasia including normal gastric antrum mucosa, reactive hyperplasia, low-grade intraepithelial neoplasia, high-grade intraepithelial ...
GUAN Xiaoying, WANG Furong
doaj   +1 more source