Results 81 to 90 of about 360,737 (315)

Proteomics Research on Gastric Intraepithelial Neoplasia

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the expression of differential proteins in the typical process of gastric intraepithelial neoplasia including normal gastric antrum mucosa, reactive hyperplasia, low-grade intraepithelial neoplasia, high-grade intraepithelial ...
GUAN Xiaoying, WANG Furong
doaj   +1 more source

Intramucosal Poorly Differentiated Adenocarcinomas Detected in a Patient with Long-Standing Ulcerative Colitis

Case Reports in Oncology, 2020
We report a case of long-standing ulcerative colitis with intramucosal well- and poorly differentiated adenocarcinomas detected over a 6-month duration.
Junichi Zaitsu, Kazuya Kuraoka, Akira Ishikawa, Hideki Yamamoto, Daiki Taniyama, Akihisa Saito, Toshio Kuwai, Yosuke Shimizu, Hirotaka Tashiro, Kiyomi Taniyama   +9 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Comparative study on the efficacy of tissue autofluorescence (visually enhanced lesion scope) and toluidine blue as a screening method in oral potentially malignant and malignant lesions

Journal of Medical Sciences, 2017
Objective and Study Design: Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. Hence, screening of such lesions and their early detection could improve prognosis.
Hasan Ali Adil, Monal Yuwanati, Aarti Singh, Suvarna Sawant, Hemant R Umarji   +4 more
doaj   +1 more source

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis

Cells
Inflammatory bowel diseases have long been recognized as entities with a higher risk of colorectal cancer. An increasing amount of information has been published regarding ulcerative colitis-associated colorectal cancer and its unique mechanisms in ...
Jesus K. Yamamoto-Furusho, Fausto D. Gutierrez-Herrera   +1 more
doaj   +1 more source

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

Guidelines for High‐Throughput Screening for Natural Products With Anti‐Aging Activity Based on Drosophila Intestinal Homeostasis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Aging represents a critical risk factor for chronic diseases, driving an urgent demand for interventions promoting healthy longevity. This study establishes standardized guidelines for high‐throughput screening (HTS) of anti‐aging natural products using Drosophila melanogaster, leveraging its intestinal homeostasis as a biomarker.
Xiao Sheng, Lei Zhang
wiley   +1 more source

Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence

Frontiers in Pediatrics, 2022
Audrey N. Miller, Audrey N. Miller, Matthew J. Kielt, Matthew J. Kielt, George T. El-Ferzli, George T. El-Ferzli, Leif D. Nelin, Leif D. Nelin, Edward G. Shepherd, Edward G. Shepherd   +9 more
doaj   +1 more source

Exploring vision transformers for classifying early Barrett's dysplasia in endoscopic images: A pilot study on white‐light and narrow‐band imaging

JGH Open
Background and Aim Various deep learning models, based on convolutional neural network (CNN), have been shown to improve the detection of early esophageal neoplasia in Barrett's esophagus.
Jin L Tan, Dileepa Pitawela, Mohamed A Chinnaratha, Andrawus Beany, Enrik J Aguila, Hsiang‐Ting Chen, Gustavo Carneiro, Rajvinder Singh   +7 more
doaj   +1 more source