Results 81 to 90 of about 50,073 (291)
Unraveling dystonia circuitry in rodent models using novel neuromodulation techniques
DystoniaDystonia is a network disorder presumed to result from abnormalities in multiple brain regions and in multiple cell populations. The specific pathomechanisms affecting the motor circuits in dystonia are, however, still largely unclear.
Lisa Rauschenberger, Chi Wang Ip
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Proximal upper limb tremor is a common, functionally disabling condition. Medical therapy is often ineffective. IncobotulinumtoxinA can significantly improve tremor with minimal adverse effects. Objectives We aimed to compare clinical, functional, and quality of life measures in patients with proximal upper limb tremor following ...
Sai A. Nagaratnam +10 more
wiley +1 more source
Subtle changes in Purkinje cell firing in Purkinje cell-specific Dyt1 ΔGAG knock-in mice
DystoniaDYT1 dystonia is an inherited early-onset generalized dystonia characterized by sustained muscle contractions causing abnormal, repetitive movements or postures.
Hong Xing +5 more
doaj +1 more source
Identifying the Diagnostic Challenges and Indicators of Orthostatic Tremor: Patient Perspectives
Movement Disorders Clinical Practice, EarlyView.Abstract Background The diagnosis of orthostatic tremor (OT) is challenging because of its non‐specific symptoms and a broad range of differential diagnosis, resulting in a complex and lengthy diagnostic journey. Objective The aim was to assess the diagnostic delay in OT and to identify key clinical indicators as reported by patients.
Wietske A. Babeliowsky +7 more
wiley +1 more source
Cerebellar contributions to dystonia: unraveling the role of Purkinje cells and cerebellar nuclei
DystoniaDystonias are a group of neurodegenerative disorders that result in altered physiology associated with motor movements. Both the basal ganglia and the cerebellum, brain regions involved in motor learning, sensory perception integration, and reward, have ...
Nichelle N. Jackson +3 more
doaj +1 more source
Molecular mechanisms in DYT-PRKRA: pathways regulated by PKR activator protein PACT
DystoniaDystonia-PRKRA (DYT-PRKRA), previously termed dystonia 16 (DYT16), is a movement disorder which currently has very limited treatments available and no cure.
Tricia A. Simon, Rekha C. Patel
doaj +1 more source
Rare GNAO1 Variant Presenting with Deep Brain Stimulation‐Responsive Jaw‐Opening Dystonia
Movement Disorders Clinical Practice, EarlyView.
Fabian Maass +4 more
wiley +1 more source
Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome
Movement Disorders Clinical Practice, EarlyView.Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert +7 more
wiley +1 more source