Divergent in situ expression of IL‐31 and IL‐31RA between bullous pemphigoid and pemphigus vulgaris
Experimental Dermatology, Volume 32, Issue 9, Page 1412-1419, September 2023., 2023 Abstract Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two major autoimmune blistering skin diseases. Unlike PV, BP is accompanied by intense pruritus, suggesting possible involvement of the pruritogenic cytokine IL‐31. However, the underlying mechanisms of the clinical difference between BP and PV in terms of pruritus are not fully ...
Ecem Zeliha Ergun +13 more
wiley +1 more source
The 'Spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families [PDF]
, 2002 Recent studies have characterised a family of giant cytoskeletal crosslinkers encoded by the short stop gene in Drosophila and the dystonin/BPAG1 and MACF1 genes in mammals.
Brown, N., Gregory, S., Roeper, K.
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Loss of the spectraplakin short stop activates the DLK injury response pathway in drosophila [PDF]
, 2013 The MAPKKK dual leucine zipper-containing kinase (DLK, Wallenda in Drosophila) is an evolutionarily conserved component of the axonal injury response pathway.
DiAntonio, Aaron +3 more
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British Journal of Haematology, Volume 200, Issue 6, Page 740-754, March 2023., 2023 Summary While the bone marrow (BM) microenvironment is significantly remodelled in acute myeloid leukaemia (AML), molecular insight into AML‐specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid‐phase BM stroma.
Diana O. Treaba +19 more
wiley +1 more source
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk. [PDF]
, 2016 We have identified eight genes whose expression in human melanoma metastases and ovarian cancers is associated with a lack of Th1 immune signatures. They encode molecules with mechanical barrier function in the skin and other normal tissues and include ...
Bedognetti, D +12 more
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BPAG1a and b associate with EB1 and EB3 and modulate vesicular transport, Golgi apparatus structure, and cell migration in C2.7 myoblasts. [PDF]
PLoS ONE, 2014 BPAG1a and BPAG1b (BPAG1a/b) constitute two major isoforms encoded by the dystonin (Dst) gene and show homology with MACF1a and MACF1b. These proteins are members of the plakin family, giant multi-modular proteins able to connect the intermediate ...
Kseniia Poliakova +6 more
doaj +1 more source
Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy [PDF]
, 2019 Distal hereditary motor neuropathies are a rare subgroup of inherited peripheral neuropathies hallmarked by a length-dependent axonal degeneration of lower motor neurons without significant involvement of sensory neurons.
Asselbergh, B +10 more
core +1 more source
International Journal of Cell Biology, 2012 Most cases of early onset DYT1 dystonia in humans are caused by a GAG deletion in the TOR1A gene leading to loss of a glutamic acid (ΔE) in the torsinA protein, which underlies a movement disorder associated with neuronal dysfunction without apparent ...
Nadia A. Atai +4 more
doaj +1 more source
Japanese Dental Science Review, 2012 This review presents information about the development of primary sensory neurons in the trigeminal nervous system. The deficiency of high affinity receptors for nerve growth factor (trkA) and neurotrophin-3 (trk-C) causesa reduction of primary ...
Hiroyuki Ichikawa +2 more
doaj +1 more source
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]
, 2010 Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P. +9 more
core +4 more sources