Results 31 to 40 of about 40,039,274 (254)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Assessing the Coordination and Spatial Equilibrium of Water, Energy, and Food Systems for Regional Socio-Economic Growth in the Ili River Valley, China

Agronomy
Water resources, energy, and food are fundamental resources for high-quality regional development. In the process of rapid regional economic growth, integrating the utilization of these fundamental resources has become a critical challenge for achieving ...
Guopeng Qin, Jian Liu, Haixia Lin, Tehseen Javed, Xuehui Gao, Yupeng Tang, Xiaoguo Mu, Muchan Guo, Zhenhua Wang   +8 more
doaj   +1 more source

Higgs boson production and decay at e+e− colliders as a probe of the Left–Right twin Higgs model

Nuclear Physics B, 2015
In the framework of the Left–Right twin Higgs (LRTH) model, we consider the constrains from the latest search for high-mass dilepton resonances at the LHC and find that the heavy neutral boson ZH is excluded with mass below 2.76 TeV.
Jinzhong Han, Shaofeng Li, Bingfang Yang, Ning Liu   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Multiscale synergistic evolution of China's water-land-energy-food-carbon system: Static-dynamic coupling analysis across sectoral, regional, and national levels

Ecological Indicators
Against the background of increasingly stringent resource and environmental constraints, the coupling among water, land, energy, food, and carbon emissions has continued to intensify, and the multi-element system has become highly complex.
Yunxing Wu, Youzhu Zhao, Delong Liu, Qiuxiang Jiang, Zilong Wang   +4 more
doaj   +1 more source

Rare observations of sprites and gravity waves supporting D, E, F-regions ionospheric coupling

Scientific Reports, 2022
We report rare simultaneous observations of columniform sprites and associated gravity waves (GWs) using the Transient Luminous Events (TLEs) camera and All-sky imager at Prayagraj (25.5° N, 81.9° E, geomag. lat. ~ 16.5° N), India.
Ajeet K. Maurya, Navin Parihar, Adarsh Dube, Rajesh Singh, Sushil Kumar, Olivier Chanrion, Maja Tomicic, Torsten Neubert   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Free energy on the sphere for non-abelian gauge theories

Journal of High Energy Physics, 2023
We compute the S d partition function of the fixed point of non-abelian gauge theories in continuous d, using the ϵ-expansion around d = 4. We illustrate in detail the technical aspects of the calculation, including all the factors arising from the gauge-
Fabiana De Cesare, Lorenzo Di Pietro, Marco Serone   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source