Results 151 to 160 of about 25,003,793 (315)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

[Works Progress Administration in Oregon]

open access: yes, 1938
[v.1]. First Congressional District of Oregon -- [v.2]. Second Congressional District of Oregon -- [v.3]. Third Congressional District of OregonThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository ...

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Current problems of educational administration in the state of Kuwait [PDF]

open access: yes, 1987
This research is an inquiry into the current problems and difficulties of educational administration in Kuwait. The study comprises eight chapters. The introduction defines the scope and purpose of the study and the methodology employed.
Al .Musailim, Muhammad Yousef
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The Community college in Canada : present status, future prospects /

open access: yes, 1971
La couv. porte en outre: Report of the proceedings of the first Annual Banff Leadership Conference on College Administration, Banff, Alberta, June 17-19 ...
Bryce, Robert   +1 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Las “ciudades digitales”: un nuevo reto para las Administraciones Públicas españolas

open access: yesÁrea Abierta, 2008
Technology´s spectacular advance and the Internet development between the Spanish citizens, allows us to speak about an absolutely digitized society.
Natalia Abuín Vences
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Grant-in-aid for the establishment of Institute of Business Administration 1966-67

open access: yes, 1967
The attached correspondence consists of email exchanges, and teleprinter messages on Grant-in-Aid received for the establishment of the Institute of Business Administration during the period 1966-67.
Institute of Business Administration, University of Karachi
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