The combination of LILRB4-targeting NK cell engagers and cGAS-STING agonists enhances the anti-multiple myeloma immune activity of NK cells. [PDF]
Li M +12 more
europepmc +1 more source
Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved or reduced ejection fraction.
Robin Willixhofer +25 more
wiley +1 more source
Beyond person-centered approaches: Integrating individual, sociodemographic and socio-spatial factors to better understand active and sustainable mobility. [PDF]
Teran-Escobar C +4 more
europepmc +1 more source
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Incorporating active commuting into daily life: a narrative review of e-bikes' impact on health and urban air quality. [PDF]
Sampieri A, Paoli A.
europepmc +1 more source
Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley +1 more source
Female cyclists' experiences of saddle sores and their effect on cycling. [PDF]
Burnie L +7 more
europepmc +1 more source
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source
The Changing Landscape of Ankle Fractures in the Era of Electric Micromobility: A Systematic Review. [PDF]
Rout S, Rout S, Patidar R.
europepmc +1 more source
Stereoselective Synthesis of Glycomimetic Amines From Biomass‐Derived Cyrene
2,3,4‐Trideoxy‐2‐mannosamines, including the unsubstituted one, are accessible as the only endo diastereoisomers by reductive amination of the green solvent Cyrene, derived from pyrolysis of cellulose containing waste biomass. The products are useful chiral synthetic intermediate to nitrogenated glycomimetics.
Debora Pratesi +4 more
wiley +1 more source

