Results 161 to 170 of about 19,795,421 (274)

A Selectfluor‐based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Chemistry – A European Journal, EarlyView.
Starting from carboxylic acids and Selectfluor‐derivatives, functionalized diazabicyclooctanes can be obtained via a novel Polonovski‐type rearrangement proceeding under mild reaction conditions. Besides their use in organic synthesis the unique structure and reactivity of the rearrangement products enables applications in medicinal chemistry ...
Jakob Kuhn, Susanne Gradl, Vanessa Osterloh, Peter Gmeiner, Harald Hübner, Markus R. Heinrich   +5 more
wiley   +1 more source

Analysis of technology acceptance and planned behavior of using shared E-biked to support the sustainable transportation development goal in smart cities. [PDF]

Front Psychol
Wang SM, Xu ZH.
europepmc   +1 more source

Mild C─F Activation of Azido(per)Fluoroalkanes

Chemistry – A European Journal, EarlyView.
Mild and selective activation of C(sp3)–F bonds in azido(per)fluoroalkanes using thiolates was developed, leading to novel functionalized azides. The reaction is initiated by nucleophilic attack of the sulfur atom to the terminal nitrogen of the azido group, followed by fluoride ion elimination.
Olena Shaitanova, María Martínez Mallo, Sergii Suikov, Blanka Klepetářová, Josef Filgas, Petr Slavíček, Lucie Bednárová, Petr Beier   +7 more
wiley   +1 more source

Development of potent Affitin-based bispecific NK cell engagers for the therapy of MSLN-expressing cancers. [PDF]

Mol Ther Oncol
Briolay T, Petithomme T, Gravoueille H, Fresquet J, Lambot S, Cossard P, Mouratou B, Fortun A, Bernardeau K, Quéméner A, Maillasson M, Boisgerault N, Mortier E, Davodeau F, Pecorari F, Blanquart C.   +15 more
europepmc   +1 more source

A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids

Chemistry – A European Journal, EarlyView.
This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci, Federica Plavi, Giovanni Viscardi, Chad N. Ungarean, Massimo Boiocchi, Christophe Salome, Quentin Lefebvre, Thomas C. Fessard, David Sarlah   +8 more
wiley   +1 more source

Configurational pathways to pediatric e-bike injury severity: an fsQCA study of global evidence. [PDF]

Front Public Health
Li Y, Li Q, Liang M.
europepmc   +1 more source

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A

Chemistry – A European Journal, EarlyView.
A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger, Maxim Munt, Le Chang, Rositsa Stoykova, Roberto Ojcius, Oliver Spieß, Dieter Schinzer   +6 more
wiley   +1 more source

PD-1 Bispecific Killer Engager (PD-1 BiKE) effectively depletes effector T lymphocytes in experimental autoimmune encephalomyelitis. [PDF]

Front Immunol
Naatz LC, Dong S, Zhai Y, Evavold B, Chen M.   +4 more
europepmc   +1 more source

Stereochemical Control in the Matteson Reaction

Chemistry – A European Journal, EarlyView.
The Matteson homologation is a highly versatile method for the stereoselective insertion of carbenoids into boronic esters. Through iterative application of the process, complex chiral molecules can be synthesized. The stereoselectivity of the reaction is determined by a chiral diol incorporated in the boronic ester.
Hae Mo Lee, Christoph Hirschhäuser
wiley   +1 more source

Uncertainty aware energy management in microgrids with integrated electric bicycle charging stations and green certificate market. [PDF]

Sci Rep
Shayeghi H, Davoudkhani IF.
europepmc   +1 more source