Results 91 to 100 of about 239,622 (310)

Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

Neoplasia: An International Journal for Oncology Research, 2008
E-cadherin is a main component of the cell-cell adhesion junctions that play a principal role in maintaining normal breast epithelial cell morphology. Breast and other cancers that have up-regulated activity of Ras are often found to have down-regulated ...
Quanwen Li, Raymond R. Mattingly
doaj   +1 more source

Expression of the E-cadherin/B-catenin complex in oral squamous cell carcinoma and its correlation with histomorphology and metastasis [PDF]

, 2006
Student No. 9404705H MDent Research Report School of Oral SciencesExpression of the E-cadherin/β-catenin complex in oral squamous cell carcinoma and its correlation with histomorphology and metastasis. The immunohistochemical expression of E-cadherin
Mahomed, Farzana
core  

Wnt/β-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer [PDF]

, 2014
BACKGROUND: β-catenin is the key protein in the WNT signalling pathway and it forms adherent junctions together with E-cadherin. In ovarian carcinoma, abnormal expression of β-catenin, E-cadherin and WNT-1 was observed, but their prognostic and ...
Aleksandra Stanczak, Cezary Szczylik, Lubomir Bodnar, Maciej Wieczorek, Marta Smoter, Marzena Cichowicz, Monika Lamparska-Przybysz, Szczepan Cierniak, Wojciech Kozlowski   +8 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

E-Cadherin Expression: A Diagnostic Utility for Differentiating Breast Carcinomas with Ductal and Lobular Morphologies [PDF]

Journal of Clinical and Diagnostic Research, 2013
Objectives: The objective of this study was to evaluate the diagnostic utility of the E-Cadherin (EC) expression in differentiating between an infiltrating ductal carcinoma (IDC) and an infiltrating lobular carcinoma (ILC), the two most common forms of
Kanthilatha Pai, Poornima Baliga, Bishwo Lal Shrestha   +2 more
doaj   +1 more source

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors [PDF]

, 2002
13 pages, 7 figures.Transcriptional repression mechanisms have emerged as one of the crucial processes for the downregulation of E-cadherin expression during development and tumour progression. Recently, several E-cadherin transcriptional repressors have
Bolós, Victoria, Peinado, Héctor, Pérez-Moreno, Mirna A., Fraga, Mario F., Esteller, Manel, Cano, Amparo   +5 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions

Journal of the Egyptian National Cancer Institute, 2014
Background: Loss of E-cadherin is a critical step for development and progression of malignant tumors. CD10; a marker of non-neoplastic and neoplastic endometrial stroma, is associated with aggressiveness of many epithelial malignancies.
Ahmed R.H. Ahmed, Eman M.S. Muhammad
doaj   +1 more source

E-cadherin evades endocytosis

The Journal of Cell Biology, 2004
![Graphic][1] E-cadherin endocytosis is blocked by IQGAP1 unless actin filaments are disrupted by Lat-A.E-cadherin interacts with other E-cadherin molecules on neighboring cells to form cell–cell adhesions.
openaire   +2 more sources

NEDD9 and BCAR1 Negatively Regulate E-Cadherin Membrane Localization, and Promote E-Cadherin Degradation

PLoS ONE, 2011
The Cas scaffolding proteins (NEDD9/HEF1/CAS-L, BCAR1/p130Cas, EFSSIN, and HEPL/CASS4) regulate cell migration, division and survival, and are often deregulated in cancer. High BCAR1 expression is linked to poor prognosis in breast cancer patients, while upregulation of NEDD9 contributes to the metastatic behavior of melanoma and glioblastoma cells ...
Nadezhda Tikhmyanova, Erica A Golemis
openaire   +4 more sources