Results 1 to 10 of about 10,734,657 (259)
Activity-Regulated N-Cadherin Endocytosis [PDF]
Neuron, 2007 Enduring forms of synaptic plasticity are thought to require ongoing regulation of adhesion molecules, such as N-cadherin, at synaptic junctions. Little is known about the activity-regulated trafficking of adhesion molecules. Here we demonstrate that surface N-cadherin undergoes a surprisingly high basal rate of internalization. Upon activation of NMDA
Tai, Chin-Yin +3 more
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Aberrant N-cadherin expression in cancer
Biomedicine and Pharmacotherapy, 2019 Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and ...
Ping Leng
exaly +3 more sources
N‐cadherin promoter polymorphisms and risk of osteoarthritis [PDF]
The FASEB Journal, 2013 Osteoarthritis (OA) is the most common form of arthritis. It is characterized by cartilage destruction and bone remodeling, mediated in part by synovial fibroblasts (SFs). Given the functional significance of cadherins in these cells, we aimed at determining the role of genetic variants of N‐cadherin (CDH2)
Ruedel, Anke +8 more
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N-cadherin, spine dynamics, and synaptic function [PDF]
frontiers in Neuroscience, 2008 Dendritic spines are one-half (the postsynaptic half) of most excitatory synapses. Ever since the direct observation over a decade ago that spines can continually change size and shape, spine dynamics has been of great research interest, especially as a mechanism for structural synaptic plasticity.
Mysore, S., Tai, C., Schuman, E.
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N-cadherin: A new player in neuronal polarity [PDF]
Cell Cycle, 2012 Comment on: Gärtner A, et al.
Gartner A, Fornasiero E, Dotti CG
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N-cadherin: stabilizing synapses [PDF]
Journal of Cell Biology, 2010 Spines are sites of excitatory synapse formation in central neurons. Alterations in spine structure and function are widely believed to actively contribute to the cellular mechanisms of learning and memory. In this issue, Mendez et al. (2010. J. Cell Biol.
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N-Cadherin Prodomain Processing Regulates Synaptogenesis [PDF]
The Journal of Neuroscience, 2012 Classical cadherins, which are adhesion molecules functioning at the CNS synapse, are synthesized as adhesively inactive precursor proteins in the endoplasmic reticulum (ER). Signal sequence and prodomain cleavage in the ER and Golgi apparatus, respectively, activates their adhesive properties.
Reines, Analia Gabriela +8 more
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N‐Cadherin is essential for retinal lamination in the zebrafish [PDF]
Developmental Dynamics, 2003 AbstractN‐Cadherin is one of the major Ca2+‐dependent cell adhesion proteins in the developing nervous system. Here, we analyze eye development in the zebrafish N‐cadherin loss‐of‐function mutant parachutepaR2.10 (pacpaR2.10). The zebrafish visual system is fully developed by the time pacpaR2.10 mutants show lethality at day 5.
Bettina, Erdmann +3 more
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N-cadherin relocalization during cardiac trabeculation [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance The process of trabeculation is central to heart development and maturation, as it allows the increase in muscle mass before the formation of coronaries. This complex process involves a number of morphological changes in a subset of cardiomyocytes, resulting in their delamination from the compact layer.
Cherian, A. +4 more
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N-cadherin antagonists as oncology therapeutics [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2015 The cell adhesion molecule (CAM), N-cadherin, has emerged as an important oncology therapeutic target. N-cadherin is a transmembrane glycoprotein mediating the formation and structural integrity of blood vessels. Its expression has also been documented in numerous types of poorly differentiated tumours.
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