Results 1 to 10 of about 2,754 (217)
Aberrant N-cadherin expression in cancer
Biomedicine and Pharmacotherapy, 2019 Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and ...
Ping Leng
exaly +3 more sources
Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis [PDF]
Journal of Dentistry, 2023 Statement of the Problem: E-cadherin and N-cadherin are two types of cell adhesion molecules that are involved in organ development, wound healing, and pathological conditions through the process of epithelial-mesenchymal transition (EMT). However, their
Hamideh Kadeh +2 more
doaj +1 more source
口腔疾病防治, 2022 Objective To investigate the role of long non-coding RNA double homeobox A pseudogene 9 (DUXAP9) in head and neck squamous cell carcinoma (HNSCC) and to evaluate the expression level, molecular function and mechanism of DUXAP9 in HNSCC cells.
ZHOU Wenkai +8 more
doaj +1 more source
Clinical Epidemiology and Global Health, 2023 Objectives: Endometrial carcinoma (EC), majority being endometroid endometrial carcinoma (EEC), is the most common invasive gynecological cancer world-wide.
Sunita Yadav +5 more
doaj +1 more source
Activity-Regulated N-Cadherin Endocytosis [PDF]
Neuron, 2007 Enduring forms of synaptic plasticity are thought to require ongoing regulation of adhesion molecules, such as N-cadherin, at synaptic junctions. Little is known about the activity-regulated trafficking of adhesion molecules. Here we demonstrate that surface N-cadherin undergoes a surprisingly high basal rate of internalization. Upon activation of NMDA
Tai, Chin-Yin +3 more
openaire +4 more sources
N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons. [PDF]
PLoS ONE, 2013 N-cadherin is a cell adhesion molecule which is enriched at synapses. Binding of N-cadherin molecules to each other across the synaptic cleft has been postulated to stabilize adhesion between the presynaptic bouton and the postsynaptic terminal.
Patricia T Yam +6 more
doaj +1 more source
Indonesian Biomedical Journal, 2021 BACKGROUND: The absence of potential biomarkers to detect the metastatic process at an early stage will consequently delay colorectal cancer (CRC) treatment.
Winarko Luminturahardjo +4 more
doaj +1 more source
N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. [PDF]
PLoS ONE, 2009 BACKGROUND: Osteoblasts are bone forming cells that play an essential role in osteogenesis. The elucidation of the mechanisms that control osteoblast number is of major interest for the treatment of skeletal disorders characterized by abnormal bone ...
Eric Haÿ +2 more
doaj +1 more source
Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists
Frontiers in Cell and Developmental Biology, 2022 This review focuses on the cell adhesion molecule (CAM), known as neural (N)-cadherin (CDH2). The molecular basis of N-cadherin-mediated intercellular adhesion is discussed, as well as the intracellular signaling pathways regulated by this CAM.
Orest W. Blaschuk
doaj +1 more source
Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons. [PDF]
PLoS ONE, 2013 Synapse elimination and pruning of axon collaterals are crucial developmental events in the refinement of neuronal circuits. While a control of synapse formation by adhesion molecules is well established, the involvement of adhesion molecules in ...
Kim N Pielarski +6 more
doaj +1 more source