Results 31 to 40 of about 156,179 (265)

N-cadherin antagonists as oncology therapeutics [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2015
The cell adhesion molecule (CAM), N-cadherin, has emerged as an important oncology therapeutic target. N-cadherin is a transmembrane glycoprotein mediating the formation and structural integrity of blood vessels. Its expression has also been documented in numerous types of poorly differentiated tumours.
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N‐Cadherin is essential for retinal lamination in the zebrafish [PDF]

Developmental Dynamics, 2003
AbstractN‐Cadherin is one of the major Ca2+‐dependent cell adhesion proteins in the developing nervous system. Here, we analyze eye development in the zebrafish N‐cadherin loss‐of‐function mutant parachutepaR2.10 (pacpaR2.10). The zebrafish visual system is fully developed by the time pacpaR2.10 mutants show lethality at day 5.
Bettina, Erdmann, Frank-P, Kirsch, Fritz G, Rathjen, Margret I, Moré   +3 more
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Progression of oral squamous cell carcinoma accompanied with reduced E-cadherin expression but not cadherin switch.

PLoS ONE, 2012
The cadherin switch from E-cadherin to N-cadherin is considered as a hallmark of the epithelial-mesenchymal transition and progression of carcinomas. Although it enhances aggressive behaviors of adenocarcinoma cells, the significance and role of cadherin
Takashi Hashimoto, Yuichi Soeno, Genta Maeda, Yuji Taya, Takaaki Aoba, Masanori Nasu, Shuichi Kawashiri, Kazushi Imai   +7 more
doaj   +1 more source

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth

eLife, 2020
Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are essential for axon outgrowth and guidance. Whether planar cell polarity (PCP) proteins, which regulate cytoskeleton dynamics and appear necessary for some axon guidance ...
Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Mikael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol   +9 more
doaj   +1 more source

Soluble N‐cadherin in human biological fluids [PDF]

International Journal of Cancer, 2006
AbstractClassical cadherins such as E‐, P‐ and N‐cadherin are transmembrane proteins that mediate cell–cell adhesion, and are important in embryogenesis, maintenance of tissue integrity and cancer. Proteolytic shedding of the extracellular domain results in the generation of soluble E‐, P‐ or N‐cadherin ectodomains.
Lara, Derycke, Olivier, De Wever, Veronique, Stove, Barbara, Vanhoecke, Joris, Delanghe, Herman, Depypere, Marc, Bracke   +6 more
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Discoidin domain receptor 1 deficiency in vascular smooth muscle cells leads to mislocalisation of N-cadherin contacts

Biology Open, 2019
N-cadherin mediates cell–cell contacts in vascular smooth muscle cells (VSMCs), and regulates VSMC behaviours including migration and proliferation. Discoidin domain receptor 1 (DDR1) is a collagen binding receptor also implicated in these processes ...
Songyi Xu, Sudarshan Bala, Michelle P. Bendeck   +2 more
doaj   +1 more source

Regulation of AMPA receptor trafficking by N‐cadherin [PDF]

Journal of Neurochemistry, 2006
AbstractDendritic spines are dynamically regulated, both morphologically and functionally, by neuronal activity. Morphological changes are mediated by a variety of synaptic proteins, whereas functional changes can be dramatically modulated by the regulation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA) receptor trafficking.
Mutsuo, Nuriya, Richard L, Huganir
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Prognostic significance of E-cadherin and N-cadherin expression in Gliomas

BMC Cancer, 2017
Background Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked to tumor invasion or metastasis, and therapeutic resistance in various human cancer.
Myung-Giun Noh, Se-Jeong Oh, Eun-Jung Ahn, Yeong-Jin Kim, Tae-Young Jung, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Kyung-Hwa Lee, Kyung-Sub Moon   +9 more
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N-cadherin relocalization during cardiac trabeculation [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance The process of trabeculation is central to heart development and maturation, as it allows the increase in muscle mass before the formation of coronaries. This complex process involves a number of morphological changes in a subset of cardiomyocytes, resulting in their delamination from the compact layer.
Cherian, A., Fukuda, N., Augustine, S., Maischein, H., Stainier, D.   +4 more
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The Leader Position of Mesenchymal Cells Expressing N-Cadherin in the Collective Migration of Epithelial Cancer

Cells, 2020
Understanding how heterogeneous cancer cell populations migrate collectively is of paramount importance to arrest metastasis. Here, we applied 3D culture-based approaches for in vitro modeling of the collective migration of squamous carcinoma cells and ...
Inés Saénz-de-Santa-María, Lucía Celada, María-Dolores Chiara   +2 more
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