Results 11 to 20 of about 10,734,657 (259)
Soluble N-cadherin fragment promotes angiogenesis [PDF]
Clinical & Experimental Metastasis, 2006 Endothelial cells express two dependent intercellular adhesion molecules: vascular endothelial (VE)-cadherin, specific for endothelial cells, and N-cadherin, also present in neuronal, lens, skeletal and heart muscle cells, osteoblasts, pericytes and fibroblasts.
DERYCKE L +5 more
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Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization [PDF]
The Journal of Cell Biology, 1998 The two major cadherins of endothelial cells are neural (N)-cadherin and vascular endothelial (VE)- cadherin. Despite similar level of protein expression only VE-cadherin is located at cell–cell contacts, whereas N-cadherin is distributed over the whole cell membrane.
P. Navarro, RUCO, Luigi, E. Dejana
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Dimeric Versions of Two Short N-cadherin Binding Motifs (HAVDI and INPISG) Function as N-cadherin Agonists [PDF]
Journal of Biological Chemistry, 2002 N-cadherin is a member of the classical cadherin family of homophilic binding molecules. Peptide competition studies have identified the HAVDI and INPISGQ sequences as functional binding motifs in extracellular domain 1 (ECD1) of N-cadherin. Whereas monomeric versions of these motifs function as specific N-cadherin antagonists, we now show that cyclic ...
Williams, G, Williams, E J, Doherty, P
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Oncotarget, 2015 Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression of N-cadherin develops metformin-resistant cancer cells, while suppression of N-cadherin sensitizes cancer to metformin. Manipulation
Ge, Rongbin +8 more
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A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]
, 2010 E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad +37 more
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Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]
, 2010 Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C Walker +18 more
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Modulatory effects of T-cadherin on cell behavior and growth factor receptor activity in carcinoma cells [PDF]
, 2014 Cancer is a major health problem. Epidermal growth factor receptor (EGFR) pathway plays an important role in cancer progression. EGFR-targeted anti-cancer drugs are being developed to improve anti-cancer therapy.
Maslova, Kseniya
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T-cadherin signaling in endothelial cells [PDF]
, 2007 The cadherin superfamily comprises transmembrane glycoproteins that mediate calciumdependent homophilic cell-cell adhesion. In addition to their pivotal role in mechanical adhesion between cells, cadherins have multiple functions in tissue ...
Joshi, Manjunath B
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, 2023 BackgroundThe cell adhesion molecule (CAM) N-cadherin has become an important target for tumor therapy. The N-cadherin antagonist, ADH-1, exerts significant antitumor activity against N-cadherin-expressing cancers.MethodsIn this study, [18F]AlF-NOTA-ADH ...
Zhenfeng Liu (431113) +23 more
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N-cadherin and E-cadherin levels in oligomycin and antimycin treated cells.
, 2021 (A) E-cadherin staining of ESCs as positive control for E-cadherin detection, Scale bar = 80 μm. Immunostaining for E-cadherin does not show detectable levels in fibroblasts, Scale bars = 15 μm.
Zhisheng Jiang (10486235) +4 more
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