N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation [PDF]
eLifeThe cell adhesion molecule N-cadherin (CDH2) is a membrane component of adherens junctions which regulates tissue morphogenesis and architecture. In the follicles of mammalian ovaries, N-cadherin adherens junctions are present between granulosa cells ...
Alaknanda Emery +9 more
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N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes [PDF]
Nature CommunicationsAdult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. Although neonatal mammalian hearts can regenerate, the underlying molecular mechanisms remain elusive.
Yi-Wei Tsai +13 more
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Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation [PDF]
JCI InsightObscurins are giant cytoskeletal proteins with structural and regulatory roles. Obscurin-B (~870 kDa), the largest known isoform, contains 2 enzymatically active Ser/Thr kinase (kin) domains, kin1 and kin2, which belong to the myosin light chain kinase ...
Li Wang +7 more
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Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis [PDF]
Journal of Dentistry, 2023 Statement of the Problem: E-cadherin and N-cadherin are two types of cell adhesion molecules that are involved in organ development, wound healing, and pathological conditions through the process of epithelial-mesenchymal transition (EMT). However, their
Hamideh Kadeh +2 more
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口腔疾病防治, 2022 Objective To investigate the role of long non-coding RNA double homeobox A pseudogene 9 (DUXAP9) in head and neck squamous cell carcinoma (HNSCC) and to evaluate the expression level, molecular function and mechanism of DUXAP9 in HNSCC cells.
ZHOU Wenkai +8 more
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Clinical Epidemiology and Global Health, 2023 Objectives: Endometrial carcinoma (EC), majority being endometroid endometrial carcinoma (EEC), is the most common invasive gynecological cancer world-wide.
Sunita Yadav +5 more
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Activity-Regulated N-Cadherin Endocytosis [PDF]
Neuron, 2007 Enduring forms of synaptic plasticity are thought to require ongoing regulation of adhesion molecules, such as N-cadherin, at synaptic junctions. Little is known about the activity-regulated trafficking of adhesion molecules. Here we demonstrate that surface N-cadherin undergoes a surprisingly high basal rate of internalization. Upon activation of NMDA
Tai, Chin-Yin +3 more
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N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons. [PDF]
PLoS ONE, 2013 N-cadherin is a cell adhesion molecule which is enriched at synapses. Binding of N-cadherin molecules to each other across the synaptic cleft has been postulated to stabilize adhesion between the presynaptic bouton and the postsynaptic terminal.
Patricia T Yam +6 more
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Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists
Frontiers in Cell and Developmental Biology, 2022 This review focuses on the cell adhesion molecule (CAM), known as neural (N)-cadherin (CDH2). The molecular basis of N-cadherin-mediated intercellular adhesion is discussed, as well as the intracellular signaling pathways regulated by this CAM.
Orest W. Blaschuk
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N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. [PDF]
PLoS ONE, 2009 BACKGROUND: Osteoblasts are bone forming cells that play an essential role in osteogenesis. The elucidation of the mechanisms that control osteoblast number is of major interest for the treatment of skeletal disorders characterized by abnormal bone ...
Eric Haÿ +2 more
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