Results 1 to 10 of about 26,522 (261)
EvoDevo, 2023 Background Cadherins are calcium-dependent transmembrane cell–cell adhesion proteins that are essential for metazoan development. They consist of three subfamilies: classical cadherins, which bind catenin, protocadherins, which contain 6–7 calcium ...
Macie M. Chess +3 more
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Roads to Stat3 Paved with Cadherins
Cells, 2022 The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
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Autoregulation of E-cadherin expression by cadherin–cadherin interactions [PDF]
The Journal of Cell Biology, 2003 Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin–β-catenin complex. We investigated the molecular basis of this regulation,
Maralice Conacci-Sorrell +5 more
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Cadherins as Matchmakers [PDF]
Neuron, 2011 Cadherins implement afferent-target matching in invertebrates, but proof for this concept in mammalian circuits has remained elusive. Two new studies in this issue of Neuron show that cadherin-6 mediates retinal ganglion cell target selection and that cadherin-9 promotes synapse specificity in the hippocampus.
Rebsam, Alexandra, Mason, Carol A.
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E-Cadherin Is Expressed in Epithelial Cells of the Choroid Plexus in Human and Mouse Brains
Current Issues in Molecular Biology, 2023 Evidence showing the functional significance of the choroid plexus is accumulating. Epithelial cells with tight and adherens junctions of the choroid plexus play important roles in cerebrospinal fluid production and circadian rhythm formation.
Genta Takebayashi +10 more
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Journal of Cell Science, 2008 The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor
Margaret J, Wheelock +4 more
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PLoS ONE, 2021 Cadherins control intercellular adhesion in most metazoans. In vertebrates, intercellular adhesion differs considerably between cadherins of type-I and type-II, predominantly due to their different extracellular regions.
Darwesh Mohideen Kaderbatcha Aladin +7 more
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Frontiers in Genetics, 2022 Background: Ischemic stroke is a highly complex disorder. This study aims to identify novel methylation changes in ischemic stroke.Methods: We carried out an epigenome-wide study of ischemic stroke using an Infinium HumanMethylation 850K array (cases ...
Hongwei Sun +11 more
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Frontiers in Neural Circuits, 2023 Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival.
Alicia N. Vagnozzi +6 more
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Differential Displacement of Classical Cadherins by VE-Cadherin [PDF]
Cell Communication & Adhesion, 2002 VE-cadherin is an endothelial cell-specific, type II classical cadherin that plays an important role in permeability, vasculogenesis, and vascular remodeling. Endothelial cells express equal levels of VE- and N-cadherin; VE-cadherin is present injunctions while N-cadherin is diffusely expressed over the surface of the cell.
Meena, Jaggi +2 more
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