Results 1 to 10 of about 28,625 (255)
Cadherins as Matchmakers [PDF]
Neuron, 2011 Cadherins implement afferent-target matching in invertebrates, but proof for this concept in mammalian circuits has remained elusive. Two new studies in this issue of Neuron show that cadherin-6 mediates retinal ganglion cell target selection and that cadherin-9 promotes synapse specificity in the hippocampus.
Rebsam, Alexandra, Mason, Carol A.
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Autoregulation of E-cadherin expression by cadherin–cadherin interactions [PDF]
The Journal of Cell Biology, 2003 Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin–β-catenin complex. We investigated the molecular basis of this regulation,
Maralice Conacci-Sorrell +5 more
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Journal of Cell Science, 2008 The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor
Margaret J, Wheelock +4 more
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Differential Displacement of Classical Cadherins by VE-Cadherin [PDF]
Cell Communication & Adhesion, 2002 VE-cadherin is an endothelial cell-specific, type II classical cadherin that plays an important role in permeability, vasculogenesis, and vascular remodeling. Endothelial cells express equal levels of VE- and N-cadherin; VE-cadherin is present injunctions while N-cadherin is diffusely expressed over the surface of the cell.
Meena, Jaggi +2 more
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Design of a Photoswitchable Cadherin [PDF]
Journal of the American Chemical Society, 2013 There is a growing interest in engineering proteins whose function can be controlled with the spatial and temporal precision of light. Here, we present a novel example of a functional light-triggered switch in the Ca-dependent cell-cell adhesion protein E-cadherin, created using a mechanism-based design strategy. We report an 18-fold change in apparent
Kortemme, Tanja +3 more
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The cadherin superfamily [PDF]
WormBook, 2005 The cadherins are a major class of membrane proteins with prominent roles in cell adhesion, and the regulation of tissue organisation and morphogenesis. The C. elegans genome encodes 13 cadherins, including representatives of the major cadherin sub-types that are conserved between insects and vertebrates: the so-called classic, Fat-like, Flamingo and ...
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Holding it together: when cadherin meets cadherin
Biophysical Journal, 2021 Intercellular adhesion is the key to multicellularity, and its malfunction plays an important role in various developmental and disease-related processes. Although it has been intensively studied by both biologists and physicists, a commonly accepted definition of cell-cell adhesion is still being debated.
Arslan, F.N. +3 more
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Regulation of Cadherin Trafficking [PDF]
Traffic, 2009 Cadherins are a large family of cell–cell adhesion molecules that tether cytoskeletal networks of actin and intermediate filaments to the plasma membrane. This function of cadherins promotes tissue organization and integrity, as demonstrated by numerous disease states that are characterized by the loss of cadherin‐based adhesion.
Emmanuella, Delva, Andrew P, Kowalczyk
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Evidence for an early cadherin-catenin interaction network in ctenophores. [PDF]
Mol Biol EvolGuttieres LJ +3 more
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Ca<sub>13</sub>Mab-17, a Novel Anti-Cadherin-13 Monoclonal Antibody for Versatile Applications. [PDF]
Antibodies (Basel)Shimizu K, Suzuki H, Kaneko MK, Kato Y.
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