Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [PDF]
, 2003 Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Aicher, A +9 more
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Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target
Frontiers in Oncology, 2019 Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and differentiation throughout life.
Weina Yu +12 more
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Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
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Cadherin Expression and EMT: A Focus on Gliomas
Biomedicines, 2021 Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination.
Carolina Noronha +6 more
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Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment
Frontiers in Cell and Developmental Biology, 2023 Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin +2 more
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The cadherin superfamily [PDF]
WormBook, 2005 The cadherins are a major class of membrane proteins with prominent roles in cell adhesion, and the regulation of tissue organisation and morphogenesis. The C. elegans genome encodes 13 cadherins, including representatives of the major cadherin sub-types that are conserved between insects and vertebrates: the so-called classic, Fat-like, Flamingo and ...
openaire +2 more sources
p120 catenin is required for the stress response in Drosophila [PDF]
, 2013 p120ctn is a ubiquitously expressed core component of cadherin junctions and essential for vertebrate development. Surprisingly, Drosophila p120ctn (dp120ctn) is dispensable for adherens junctions and development, which has discouraged Drosophila ...
Bauer, Christin +2 more
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The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer
International Brazilian Journal of Urology, 2011 During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β
Alexandros Drivalos +4 more
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Cells, 2022 Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer ...
Nayden G. Naydenov +9 more
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Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells [PDF]
, 2010 Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related death worldwide. Current treatments are extremely disappointing.
Alaniz, Laura Daniela +8 more
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