Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment [PDF]
Frontiers in Cell and Developmental Biology, 2023 Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin +2 more
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LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment [PDF]
Biology Direct, 2023 Background Malignant melanoma is a highly heterogeneous skin cancer with the highest mortality rate among dermatological cancers. Catenins form functional networks in the nucleus to regulate gene expression and determine cell fate.
Yi-dou Hu +7 more
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Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window [PDF]
Frontiers in Neural Circuits, 2023 Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival.
Alicia N. Vagnozzi +6 more
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p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro [PDF]
Frontiers in Cellular Neuroscience, 2023 Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia.
Maxsam S. Donta +9 more
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Beta-catenin versus the other catenins: assessing our current view of canonical Wnt signaling [PDF]
Progress in Molecular Biology and Translational Science, 2013 The prevailing view of canonical Wnt signaling emphasizes the role of beta-catenin acting downstream of Wnt activation to regulate transcriptional activity.
Rachel K. Miller +3 more
semanticscholar +2 more sources
The potential involvement of E-cadherin and beta-catenins in meningioma. [PDF]
PLoS ONE, 2010 OBJECTIVE: To investigate the potential involvements of E-cadherin and beta-catenin in meningioma. METHODS: Immunohistochemistry staining was performed on samples from patients with meningioma.
Keiyu Zhou +5 more
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Actin-dependent α-catenin oligomerization contributes to adherens junction assembly [PDF]
Nature CommunicationsClassic cadherins, specifically E-cadherin in most epithelial cells, are transmembrane adhesion receptors, whose intracellular region interacts with proteins, termed catenins, forming the cadherin-catenin complex (CCC).
Regina B. Troyanovsky +2 more
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A transphyletic study of metazoan β-catenin protein complexes [PDF]
Zoological LettersBeta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development.
Ivan Mbogo +9 more
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Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.
Journal of Cell Biology, 1995 The extracellular segment of the receptor-type type protein tyrosine phosphatase PTPmu, possesses an MAM domain, an immunoglobulin domain, and four fibronectin type-III repeats.
Tonks N K
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Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac
Journal of Cell Biology, 2004 Using an animal model system and depletion-rescue strategies, we have addressed the requirement and functions of armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) and p120 catenins in early vertebrate embryogenesis. We find that xARVCF
Jae-Il Park +2 more
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