Results 31 to 40 of about 10,852 (292)
Structure of the Dimerization and β-Catenin- Binding Region of α-Catenin [PDF]
Molecular Cell, 2000 In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix ...
Pokutta, Sabine, Weis, William I.
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Beyond β-catenin: prospects for a larger catenin network in the nucleus [PDF]
Nature Reviews Molecular Cell Biology, 2015 β-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins that are structurally related to β-catenin, and three α-catenin genes encoding actin-binding proteins that are structurally related to vinculin.
Pierre D, McCrea, Cara J, Gottardi
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Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
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Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.
Folia Histochemica et Cytobiologica, 2010 Cadherins and catenins, mediators of intercellular interactions, play a major role in adhesion. Changes in their expression and functioning reflect invasive and metastatic properties of cancer cells.
Katarzyna Guzińska-Ustymowicz +3 more
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Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. [PDF]
PLoS ONE, 2014 Members of the plakophilin-catenin sub-family (Pkp-1, -2, and -3) facilitate the linkage of desmosome junctional components to each other (e.g. desmosomal cadherins to desmoplakin) and the intermediate-filament cytoskeleton.
William A Munoz +9 more
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Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity
Cell Adhesion & Migration, 2023 E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promoting epithelial cell adhesion, but the mechanism remains ...
Maha Abedrabbo +4 more
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p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction [PDF]
Molecular and Cellular Biology, 2003 beta-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and alpha-catenin. We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases.
Jose, Piedra +6 more
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Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]
, 2016 1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D +4 more
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Folia Histochemica et Cytobiologica, 2010 The E-cadherin-catenin complex plays an important role in the process of cell adhesion. Its dysfunction is associated with a decrease in cell differentiation and with increased invasiveness and metastasis.
Marek Ustymowicz +4 more
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Journal of the American Society of Nephrology, 2011 Congenital anomalies of the kidney and urinary tract are the single most common cause of renal failure in childhood. Advances in the care of children with renal failure has primarily focused on optimizing the supportive, although nonspecific, treatment of chronic kidney disease and in addressing ...
Jacqueline Ho, Carlton M. Bates
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