Results 41 to 50 of about 5,972 (292)

Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma

, 1998
The immunocytochemical expression of cadherins and catenins was examined during the process of oral carcinogenesis by comparing their expression in normal and dysplastic epithelium with primary and metastatic carcinomas.
Williams, H K, Landini, G.; id_orcid, Sanders, D.S.A., Jankowski, J.A.Z., Brown, A.M.S.   +4 more
core   +1 more source

Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae)

Brazilian Journal of Biology
Cell adhesion molecules act as signal transducers from the extracellular environment to the cytoskeleton and the nucleus and consequently induce changes in the expression pattern of structural proteins.
MF. Izaguirre, MN. García-Sancho, LA. Miranda, J. Tomas, VH. Casco   +4 more
doaj   +1 more source

The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer

International Brazilian Journal of Urology, 2011
During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β
Alexandros Drivalos, Athanasios G. Papatsoris, Michael Chrisofos, Eleni Efstathiou, Meletios A. Dimopoulos   +4 more
doaj   +1 more source

Evolution of cadherins and associated catenins

, 2016
During more than 600 Ma of multicellular animal evolution, the cadherin superfamily has become strikingly diverse, both structurally and functionally. Cadherins are typically transmembrane proteins with an ectodomain comprising so-called cadherin repeats.
Frans van Roy, Ismail Sahin Gul, Van Roy, Frans, Paco Hulpiau, Gül, Ismail Sahin, Hulpiau, Paco   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation

Biomolecules, 2019
Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role
Raf Van Campenhout, Sara Crespo Yanguas, Axelle Cooreman, Eva Gijbels, Kaat Leroy, Vânia Vilas-Boas, Nick Devoogdt, Serge Muyldermans, Bruno Cogliati, Mathieu Vinken   +9 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Tumor suppressor gene E-cadherin and its role in normal and malignant cells

Cancer Cell International, 2003
E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of ...
Pećina-Šlaus Nives
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. [PDF]

PLoS Biology, 2010
Wnt signalling pathways have extremely diverse functions in animals, including induction of cell fates or tumours, guidance of cell movements during gastrulation, and the induction of cell polarity.
Juan Cabello, Lukas J Neukomm, Ufuk Günesdogan, Katharina Burkart, Steve J Charette, Günter Lochnit, Michael O Hengartner, Ralf Schnabel   +7 more
doaj   +1 more source