Results 1 to 10 of about 65,583 (163)
Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. [PDF]
Journal of Cell Biology, 1995 Cadherins are Ca(2+)-dependent, cell surface glycoproteins involved in cell-cell adhesion. Extracellularly, transmembrane cadherins such as E-, P-, and N-cadherin self-associate, while intracellularly they interact indirectly with the actin-based cytoskeleton.
K A, Knudsen +3 more
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Frontiers in Neuroscience, 2016 The molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) are still not fully understood. In AD, Wnt/beta-catenin signaling has been shown to be downregulated while the peroxisome proliferator-activated receptor (PPAR) gamma ...
Alexandre Vallée +2 more
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Pharmaceuticals, 2021 AlphaN-catenin gene CTNNA2 has been implicated in intrauterine brain development, as well as in several psychiatric disorders and cardiovascular diseases. Our present aim was to investigate CTNNA2 gene-wide associations of single-nucleotide polymorphisms
, Zsolt Bagyura, György Bagdy
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The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1991 The cytoplasmic region of the Ca(2+)-dependent cell-adhesion molecule (CAM) uvomorulin associates with distinct cytoplasmic proteins with molecular masses of 102, 88, and 80 kDa termed alpha, beta, and gamma catenin, respectively. This complex formation links uvomorulin to the actin filament network, which seems to be of primary importance for its cell-
C Eckerskorn, Rolf Kemler, Kemler R
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p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. [PDF]
PLoS ONE, 2010 Adherens junctions consist of transmembrane cadherins, which interact intracellularly with p120ctn, beta-catenin and alpha-catenin. p120ctn is known to regulate cell-cell adhesion by increasing cadherin stability, but the effects of other adherens ...
Sandra Kümper, Anne J Ridley
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Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. [PDF]
PLoS ONE, 2012 Alpha (α)-E-catenin is a component of the cadherin complex, and has long been thought to provide a link between cell surface cadherins and the actin skeleton.
Sumeda Nandadasa +4 more
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Signaling function of α-catenin in microtubule regulation [PDF]
Cell Cycle, 2008 Centrosomes control microtubule dynamics in many cell types, and their removal from the cytoplasm leads to a shift from dynamic instability to treadmilling behavior and to a dramatic decrease of microtubule mass (Rodionov et al., 1999; PNAS 96:115).
Michael, Shtutman +9 more
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Folia Histochemica et Cytobiologica, 2010 The E-cadherin-catenin complex plays an important role in the process of cell adhesion. Its dysfunction is associated with a decrease in cell differentiation and with increased invasiveness and metastasis.
Marek Ustymowicz +4 more
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Structure of the Dimerization and β-Catenin- Binding Region of α-Catenin [PDF]
Molecular Cell, 2000 In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix ...
Pokutta, Sabine, Weis, William I.
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The evolutionary history of the catenin gene family during metazoan evolution
BMC Evolutionary Biology, 2011 Background Catenin is a gene family composed of three subfamilies; p120, beta and alpha. Beta and p120 are homologous subfamilies based on sequence and structural comparisons, and are members of the armadillo repeat protein superfamily.
Reynolds Albert B +2 more
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