Results 11 to 20 of about 65,682 (262)
Prognostic roles of pathology markers immunoexpression and clinical parameters in Hepatoblastoma
Journal of Biomedical Science, 2017 Background Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive hepatic stem cells. We aimed to elucidate the relationships between the histological distribution of β-catenin and hepatic stem cell markers ...
Jia-Feng Wu +6 more
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Molecular Cloning of an Alternative Human αE-Catenin cDNA [PDF]
Biochemical and Biophysical Research Communications, 1997 The cytoplasmic protein alpha-catenin plays a crucial role in E-cadherin mediated cell-cell adhesion by binding E-cadherin to the cytoskeleton via beta- or gamma-catenin and actin. Functional loss of one of these interacting components leads to decreased cell-cell adhesion, and therefore to loss of epithelial integrity.
Linkels, M. +5 more
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Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.
Folia Histochemica et Cytobiologica, 2010 Cadherins and catenins, mediators of intercellular interactions, play a major role in adhesion. Changes in their expression and functioning reflect invasive and metastatic properties of cancer cells.
Katarzyna Guzińska-Ustymowicz +3 more
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Nutrition & Metabolism, 2022 Background Altered lipid profiles are frequently present in cancer, and it is necessary to elucidate the role of changed lipid profiles in hepatocellular carcinoma (HCC). We conducted this study to investigate the changed lipid profile in HCC tissues and
Shu Feng +5 more
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Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration
Journal of Orthopaedic Surgery and Research, 2021 Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
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Alpha-Catenins Control Cardiomyocyte Proliferation by Regulating Yap Activity [PDF]
Circulation Research, 2015 Rationale: Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. Thus, they are unable to effectively replace dying cells in the injured heart. The recent discovery that the transcriptional coactivator Yes-associated protein (Yap) is necessary and sufficient for ...
Li, J. +7 more
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Фактори експериментальної еволюції організмів, 2017 Aim. In our present work, we have addressed to the γ-catenin, known main component of desmosomes, expression in hearts with heterozygous and homozygous knockout of α-E-catenin gene. Methods. Alpha-E-catenin conditional knockout mice were bred with α-MHC-
V. V. Balatskyi +2 more
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Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1. [PDF]
PLoS ONE, 2008 Previous studies have indicated that Epstein-Barr virus (EBV) can modulate the Wnt pathway in virus-infected cells and this effect is mediated by EBV-encoded oncogene latent membrane protein 1 (LMP1).
Natasha Webb +4 more
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Identification of the Domain of α-Catenin Involved in Its Association with β-Catenin and Plakoglobin (γ-Catenin) [PDF]
Journal of Biological Chemistry, 1997 alpha-Catenin is a 102-kDa protein exhibiting homology to vincuin, and it forms complexes with cadherins or the tumor-suppressor gene product adenomatous polyposis coli through binding to beta-catenin or plakoglobin (gamma-catenin). The incorporation of alpha-catenin into the cadherin-catenin complexes is a prerequisite for expression of the cell ...
H, Obama, M, Ozawa
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Chinese Journal of Lung Cancer, 2011 Background and objective Our previous in vivo experiment (paper has been published) has confirmed Feiyanning’s regulation effect on epithelial cell markers Alpha-catenin, beta-catenin, E-Cadherin and mesenchymal cell markers N-cadherin, Fibronectin ...
Xiaozhen ZHAO +5 more
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