Results 31 to 40 of about 65,682 (262)

Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

Molecular Medicine, 2022
Background Arteriovenous fistula (AVF) is the most important vascular access for hemodialysis; however, preventive treatment to maintain the patency of AVFs has not been developed.
Chung-Te Liu, Shih-Chang Hsu, Hui-Ling Hsieh, Cheng-Hsien Chen, Chun-You Chen, Yuh-Mou Sue, Tso-Hsiao Chen, Yung-Ho Hsu, Feng-Yen Lin, Chun-Ming Shih, Yan-Ting Shiu, Po-Hsun Huang   +11 more
doaj   +1 more source

α-Catenin is essential in intestinal adenoma formation [PDF]

Proceedings of the National Academy of Sciences, 2007
A loss-of-function mutation in the APC gene initiates colorectal carcinogenesis. Although the molecular mechanism of tumor initiation is complex, several modifier genes have been identified using mouse models, including the ApcMin mouse.
Hiroyuki, Shibata, Hiroshi, Takano, Masaki, Ito, Hisashi, Shioya, Morihisa, Hirota, Hiroshi, Matsumoto, Yuichi, Kakudo, Chikashi, Ishioka, Tetsu, Akiyama, Yumi, Kanegae, Izumu, Saito, Tetsuo, Noda   +11 more
openaire   +2 more sources

ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells

iScience, 2018
Summary: Cardiac development requires coordinated biphasic regulation of the WNT/β-catenin signaling pathway. By intersecting gene expression and loss-of-function siRNA screens we identified Alpha Protein Kinase 2 (ALPK2) as a candidate negative ...
Peter Hofsteen, Aaron Mark Robitaille, Nicholas Strash, Nathan Palpant, Randall T. Moon, Lil Pabon, Charles E. Murry   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. [PDF]

PLoS ONE, 2009
BACKGROUND:Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/beta ...
Desheng Lu, Jerry X Liu, Tomoyuki Endo, Haowen Zhou, Shiyin Yao, Karl Willert, Ingo G H Schmidt-Wolf, Thomas J Kipps, Dennis A Carson   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

Nature Communications, 2021
Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ.
Mariana Pavel, So Jung Park, Rebecca A. Frake, Sung Min Son, Marco M. Manni, Carla F. Bento, Maurizio Renna, Thomas Ricketts, Fiona M. Menzies, Radu Tanasa, David C. Rubinsztein   +10 more
doaj   +1 more source

α-Catenin overrides Src-dependent activation of β-catenin oncogenic signaling [PDF]

Molecular Cancer Therapeutics, 2008
Abstract Loss of α-catenin is one of the characteristics of prostate cancer. The catenins (α and β) associated with E-cadherin play a critical role in the regulation of cell-cell adhesion. Tyrosine phosphorylation of β-catenin dissociates it from E-cadherin and facilitates its entry into the nucleus, where β-catenin acts as a ...
Landon J, Inge, Sigrid A, Rajasekaran, Daniel, Wolle, Sonali P, Barwe, Sergey, Ryazantsev, Charles M, Ewing, William B, Isaacs, Ayyappan K, Rajasekaran   +7 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

αE-catenin is not a significant regulator of β-catenin signaling in the developing mammalian brain [PDF]

Journal of Cell Science, 2008
β-catenin is a crucial mediator of the canonical Wnt-signaling pathway. α-catenin is a major β-catenin-binding protein, and overexpressed α-catenin can negatively regulate β-catenin activity. Thus, α-catenin may be an important modulator of the Wnt pathway.
Wen-Hui, Lien, Olga, Klezovitch, Manda, Null, Valeri, Vasioukhin   +3 more
openaire   +2 more sources