Results 11 to 20 of about 5,972 (292)
Expression of β-Catenin and γ-Catenin in Maxillary Bone Regeneration [PDF]
International Journal of Immunopathology and Pharmacology, 2011 β- and γ-catenin are components of catenin family involved in cadherin adhesion function. Recently it has been shown that this family is involved in other functions such as signaling and activation of transcription factors. The final goal of this study was to evaluate the role of β- and γ-catenin in bone cell physiology and bone regeneration.
A. SANTARELLI +10 more
core +6 more sources
Exchange of catenins in cadherin–catenin complex [PDF]
Oncogene, 2003 beta-Catenin is an intracellular multifunctional protein. In complex with the transmembrane adhesive receptor E-cadherin, it becomes plasma membrane-associated and mediates intercellular adhesion. A cytosolic pool of beta-catenin interacts with DNA-binding proteins and participates in signal transduction. To reveal the possible cross-talk between these
Klingelhöfer, Jörg +3 more
openaire +3 more sources
JHEP Reports, 2023 Background & Aims: β-catenin is a well-known effector of the Wnt pathway, and a key player in cadherin-mediated cell adhesion. Oncogenic mutations of β-catenin are very frequent in paediatric liver primary tumours.
Caroline Gest +19 more
doaj +1 more source
Identification of the Domain of α-Catenin Involved in Its Association with β-Catenin and Plakoglobin (γ-Catenin) [PDF]
Journal of Biological Chemistry, 1997 alpha-Catenin is a 102-kDa protein exhibiting homology to vincuin, and it forms complexes with cadherins or the tumor-suppressor gene product adenomatous polyposis coli through binding to beta-catenin or plakoglobin (gamma-catenin). The incorporation of alpha-catenin into the cadherin-catenin complexes is a prerequisite for expression of the cell ...
H, Obama, M, Ozawa
openaire +2 more sources
The catenin family at a glance [PDF]
Journal of Cell Science, 2010 Members of the catenin family were first isolated complexed with the cytoplasmic domains of cadherins at cell-cell junctions, and this relationship is considered one of the defining aspects of catenins. Their functions at such contacts are multifaceted and remain under active study and discussion.
Pierre D, McCrea, Dongmin, Gu
openaire +2 more sources
The potential involvement of E-cadherin and beta-catenins in meningioma. [PDF]
PLoS ONE, 2010 OBJECTIVE: To investigate the potential involvements of E-cadherin and beta-catenin in meningioma. METHODS: Immunohistochemistry staining was performed on samples from patients with meningioma.
Keiyu Zhou +5 more
doaj +1 more source
Structure of the Dimerization and β-Catenin- Binding Region of α-Catenin [PDF]
Molecular Cell, 2000 In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix ...
Pokutta, Sabine, Weis, William I.
openaire +2 more sources
Beyond β-catenin: prospects for a larger catenin network in the nucleus [PDF]
Nature Reviews Molecular Cell Biology, 2015 β-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins that are structurally related to β-catenin, and three α-catenin genes encoding actin-binding proteins that are structurally related to vinculin.
Pierre D, McCrea, Cara J, Gottardi
openaire +2 more sources
Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.
Folia Histochemica et Cytobiologica, 2010 Cadherins and catenins, mediators of intercellular interactions, play a major role in adhesion. Changes in their expression and functioning reflect invasive and metastatic properties of cancer cells.
Katarzyna Guzińska-Ustymowicz +3 more
doaj +1 more source
Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. [PDF]
PLoS ONE, 2014 Members of the plakophilin-catenin sub-family (Pkp-1, -2, and -3) facilitate the linkage of desmosome junctional components to each other (e.g. desmosomal cadherins to desmoplakin) and the intermediate-filament cytoskeleton.
William A Munoz +9 more
doaj +1 more source