Results 51 to 60 of about 30,352 (298)
Cells, 2022 Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer ...
Nayden G. Naydenov +9 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Coordinated cadherin functions sculpt respiratory motor circuit connectivity
eLife, 2022 Breathing, and the motor circuits that control it, is essential for life. At the core of respiratory circuits are Dbx1-derived interneurons, which generate the rhythm and pattern of breathing, and phrenic motor neurons (MNs), which provide the final ...
Alicia N Vagnozzi +10 more
doaj +1 more source
Adhesion Molecules. I: Keratinocyte-Keratinocyte Interactions; Cadherins and Pemphigus [PDF]
, 1995 During the last few years, considerable progress has been made in our understanding of the structure and function of cadherins and of the pathophysiology of pemphigus.
Amagai, Masayuki
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Review on Host-Leptospira Interactions: What We Know and Future Expectations
Frontiers in Cellular and Infection Microbiology, 2021 Leptospirosis is a widespread zoonosis caused by pathogenic Leptospira spp. It is considered a neglected infectious disease of human and veterinary concern.
Brenda B. Daroz +15 more
doaj +1 more source
, 2016 The desmosomal cadherins (DCs) are adhesion molecules of desmosomes,intercellular junctions of epithelia and cardiac muscle. DCs have the uniqueability to adopt a hyperadhesive state that is characterised by enhanced stability and adhesive strength ...
Chidgey, Martyn +3 more
core +1 more source
Cadherins: cellular adhesive molecules serving as signalling mediators [PDF]
, 2018 The single pass, transmembrane proteins of the cadherin family have been appreciated as important proteins that regulate intercellular adhesion. In addition to this critical function, cadherins contribute to important signalling events that control ...
Kusters, Dennis H. M. +5 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
3-Dimensional reconstruction reveals frequent intraluminal growth of submucosal veins in surgically resected pT1 colorectal cancers [PDF]
Journal of Pathology and Translational MedicineBackground Although venous invasion (VI) is associated with distant metastasis and observed in >50% of pT2–4 colorectal cancers (CRCs), the role of VI in pT1 CRCs is not well-defined.
Jihyun Park +11 more
doaj +1 more source