Results 71 to 80 of about 30,352 (298)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Dental Research JournalBackground: Accurate and early diagnosis of dysplastic lesions is crucial for successful treatment. A decrease in E-cadherin expression has been observed in dysplastic lesions and tumors. Therefore, the aim of this study was to investigate the expression
Laleh Maleki +3 more
doaj +1 more source
Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt
Biomolecular Concepts, 2015 Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function. Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3 ...
Niit Maximilian +6 more
doaj +1 more source
Biophysical Tools to Study Cellular Mechanotransduction
Bioengineering, 2017 The cell membrane is the interface that volumetrically isolates cellular components from the cell’s environment. Proteins embedded within and on the membrane have varied biological functions: reception of external biochemical signals, as membrane ...
Ismaeel Muhamed +2 more
doaj +1 more source
Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation
Frontiers in Cell and Developmental Biology, 2021 The segregation of distinct cell populations to form sharp boundaries is crucial for stabilising tissue organisation, for example during hindbrain segmentation in craniofacial development.
David G. Wilkinson
doaj +1 more source
Identification of Novel Cadherins Expressed in Human Melanoma Cells [PDF]
, 1997 Cadherin molecules are essential for tissue morphogenesis and are also related to cancer invasion and metastasis. Although normal melanocytes express E- and P-cadherin, the activity and expression of E- and P-cadherin in melanoma cells are still unknown.
Matsuyoshi, Norihisa +3 more
core +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Regulation of Cadherin Trafficking [PDF]
Traffic, 2009 Cadherins are a large family of cell–cell adhesion molecules that tether cytoskeletal networks of actin and intermediate filaments to the plasma membrane. This function of cadherins promotes tissue organization and integrity, as demonstrated by numerous disease states that are characterized by the loss of cadherin‐based adhesion.
Emmanuella, Delva, Andrew P, Kowalczyk
openaire +2 more sources
Nonchordate Classic Cadherins Have a Structurally and Functionally Unique Domain That Is Absent from Chordate Classic Cadherins [PDF]
, 1999 Classic cadherins, which are adhesion molecules in cell-cell adherens junctions, have a large contribution to the construction of the animal body. Their molecular structures show clear differences between chordate and nonchordate metazoans.
Tsukita, Shoichiro, Oda, Hiroki
core +1 more source
Retinal cadherins and the retinal cadherinopathies: current concepts and future directions [PDF]
, 2022 Cadherins are a superfamily of calcium-dependent intercellular adhesion molecules that are widely expressed in living tissues. Within the retina and retinal pigment epithelium (RPE), cadherins contribute to tissue morphogenesis, neural circuit formation,
Garrett, Andrew +3 more
core +1 more source