Results 61 to 70 of about 30,352 (298)

Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly [version 1; peer review: 1 approved, 2 approved with reservations]

F1000Research, 2022
Background: Arising at distinct positions in the head, the cranial ganglia are crucial for integrating various sensory inputs. The largest of these ganglia is the trigeminal ganglion, which relays pain, touch and temperature information through its three
Chyong-Yi Wu, Lisa A. Taneyhill, Caroline A. Halmi   +2 more
doaj   +1 more source

Cadherin specificity in adhesion and mechanotransduction [PDF]

, 2009
Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes.
Shi, Quanming
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse

Frontiers in Molecular Neuroscience, 2021
Type I and type II classical cadherins comprise a family of cell adhesion molecules that regulate cell sorting and tissue separation by forming specific homo and heterophilic bonds.
Julie Polanco, Fredy Reyes-Vigil, Sarah D. Weisberg, Ilirian Dhimitruka, Juan L. Brusés   +4 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

New insights into the evolution of metazoan cadherins and catenins

, 2013
E-Cadherin and b-catenin are the best studied representatives of the superfamilies of transmembrane cadherins and intracellular armadillo catenins, respectively.
Gül, Ismail SahinUGent00007100197680200106693597975271727416E6D8D0-F0EE-11E1-A9DE-61C894A0A6B4, Hulpiau, PacoCA20801001334112F5BB79FE-F0ED-11E1-A9DE-61C894A0A6B4, Van Roy, FranseditorUGent801000301767977669338544F3A1597C-F0ED-11E1-A9DE-61C894A0A6B4, Van Roy, FransUGent801000301767977669338544F3A1597C-F0ED-11E1-A9DE-61C894A0A6B4   +3 more
core   +2 more sources

N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity

Nature Communications
Mesenchymal stem cells (MSCs) interact with their surroundings via integrins, which link to the actin cytoskeleton and translate physical cues into biochemical signals through mechanotransduction.
Eva Barcelona-Estaje, Mariana A. G. Oliva, Finlay Cunniffe, Aleixandre Rodrigo-Navarro, Paul Genever, Matthew J. Dalby, Pere Roca-Cusachs, Marco Cantini, Manuel Salmeron-Sanchez   +8 more
doaj   +1 more source

Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates [PDF]

Exploration of BioMat-X
Aim: This study evaluated the impact of retinal extracellular matrix (ECM) and key biomaterial substrates on the motility of transplantable retinal cells with genomic manipulation, using the therapeutic molecule, Topoisomerase II beta (Top2b), as a model.
Alexandra C. Dabrowski, Alexandria R. Logan, Rameshwari Rayaji, Brianna Rodriguez, Li Cai, Maribel Vazquez   +5 more
doaj   +1 more source

Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus [PDF]

, 2017
Hippocampal CA3 neurons form synapses with CA1 neurons in two layers, stratum oriens (SO) and stratum radiatum (SR). Each layer develops unique synaptic properties but molecular mechanisms that mediate these differences are unknown. Here, we show that SO
Taylor, Matthew, Masahito Yamagata, Sujan C. Das, Shruti Muralidhar, Das, Sujan, Gangi-Wellman, Luke, Basu, Raunak, Matthew R. Taylor, Martin, E, Peter J. West, Xin Duan, Duan, Xin, Yamagata, Masahito, Sanes, Joshua, Luke Gangi-Wellman, West, Peter, Joshua R. Sanes, Muralidhar, Shruti, Yueqi Wang, Raunak Basu, Megan E. Williams, Wang, Yueqi, E. Anne Martin, Williams, Megan   +23 more
core   +1 more source