Results 41 to 50 of about 30,352 (298)
Microtubules and cadherins: a neglected partnership
, 2009 Classical cadherins are fundamental determinants of tissue organization both in health and disease. It has long been recognized that cadherins function in close cooperation with the cytoskeleton, particularly with actin.
Akhmanova, A +7 more
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Biomolecules, 2021 Pemphigus and pemphigoid diseases are potentially life-threatening autoimmune blistering disorders that are characterized by intraepithelial and subepithelial blister formation, respectively. In both disease groups, skin and/or mucosal blistering develop
Nicola Cirillo, Stephen S. Prime
doaj +1 more source
Cadherins in the human placenta : epithelial-mesenchymal transition (EMT) and placental development
, 2010 Colonisation of the maternal uterine wall by the trophoblast involves a series of alterations in the behaviour and morphology of trophoblast cells. Villous cytotrophoblast cells change from a well-organised coherently layered phenotype to one that is ...
R. Wafai +9 more
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Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MKN45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene [PDF]
Middle East Journal of CancerBackground: The treatment of gastric cancer (GC) is still quite challenging. Yet, marine invertebrates have been found to produce a wide range of anticancer bioactive compounds that show promise in fighting cancer.
Khadijeh Sadegh +3 more
doaj +1 more source
E-cadherin binds to desmoglein to facilitate desmosome assembly
eLife, 2018 Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the
Omer Shafraz +6 more
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Cadherin Expression and EMT: A Focus on Gliomas
Biomedicines, 2021 Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination.
Carolina Noronha +6 more
doaj +1 more source
Holding it together: when cadherin meets cadherin
Biophysical Journal, 2021 Intercellular adhesion is the key to multicellularity, and its malfunction plays an important role in various developmental and disease-related processes. Although it has been intensively studied by both biologists and physicists, a commonly accepted definition of cell-cell adhesion is still being debated.
Arslan, F.N. +3 more
openaire +5 more sources
Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment
Frontiers in Cell and Developmental Biology, 2023 Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin +2 more
doaj +1 more source
Evolution of cadherins and associated catenins
, 2016 During more than 600 Ma of multicellular animal evolution, the cadherin superfamily has become strikingly diverse, both structurally and functionally. Cadherins are typically transmembrane proteins with an ectodomain comprising so-called cadherin repeats.
Frans van Roy +5 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source