Results 21 to 30 of about 30,352 (298)

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling.

PLoS ONE, 2021
Cadherins control intercellular adhesion in most metazoans. In vertebrates, intercellular adhesion differs considerably between cadherins of type-I and type-II, predominantly due to their different extracellular regions.
Darwesh Mohideen Kaderbatcha Aladin, Yeh Shiu Chu, Shuo Shen, Robert Charles Robinson, Sylvie Dufour, Virgile Viasnoff, Nicolas Borghi, Jean Paul Thiery   +7 more
doaj   +1 more source

Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population

Frontiers in Genetics, 2022
Background: Ischemic stroke is a highly complex disorder. This study aims to identify novel methylation changes in ischemic stroke.Methods: We carried out an epigenome-wide study of ischemic stroke using an Infinium HumanMethylation 850K array (cases ...
Hongwei Sun, Jia Xu, Bifeng Hu, Yue Liu, Yun Zhai, Yanyan Sun, Hongwei Sun, Fang Li, Jiamin Wang, Anqi Feng, Ying Tang, Jingbo Zhao   +11 more
doaj   +1 more source

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window

Frontiers in Neural Circuits, 2023
Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival.
Alicia N. Vagnozzi, Matthew T. Moore, Raquel López de Boer, Aambar Agarwal, Niccolò Zampieri, Lynn T. Landmesser, Polyxeni Philippidou   +6 more
doaj   +1 more source

Differential Displacement of Classical Cadherins by VE-Cadherin [PDF]

Cell Communication & Adhesion, 2002
VE-cadherin is an endothelial cell-specific, type II classical cadherin that plays an important role in permeability, vasculogenesis, and vascular remodeling. Endothelial cells express equal levels of VE- and N-cadherin; VE-cadherin is present injunctions while N-cadherin is diffusely expressed over the surface of the cell.
Meena, Jaggi, Margaret J, Wheelock, Keith R, Johnson   +2 more
openaire   +2 more sources

Design of a Photoswitchable Cadherin [PDF]

Journal of the American Chemical Society, 2013
There is a growing interest in engineering proteins whose function can be controlled with the spatial and temporal precision of light. Here, we present a novel example of a functional light-triggered switch in the Ca-dependent cell-cell adhesion protein E-cadherin, created using a mechanism-based design strategy. We report an 18-fold change in apparent
Kortemme, Tanja, Ritterson, RS, Kuchenbecker, KM, Michalik, M   +3 more
openaire   +4 more sources

Cadherins as regulators of neuronal polarity [PDF]

, 2015
A compelling amount of data is accumulating about the polyphonic role of neuronal cadherins during brain development throughout all developmental stages, starting from the involvement of cadherins in the organization of neurulation up to synapse ...
Fornasiero, Eugenio F., Dotti, Carlos, Gärtner, Annette, Gätner, Annette, Dotti, Carlos G.   +4 more
core   +2 more sources

Trichomonas vaginalis: Monolayer and Cluster Formation—Ultrastructural Aspects Using High-Resolution Scanning Electron Microscopy

Pathogens, 2023
Trichomonas vaginalis is an extracellular protozoan parasite that causes human trichomoniasis, a sexually transmitted infection (STI) that affects approximately 270 million people worldwide. The phenomenon of T. vaginalis adhesion to inert substrates has
Sharmila Fiama das Neves Ortiz, Raphael Verdan, Fabio da Silva de Azevedo Fortes, Marlene Benchimol   +3 more
doaj   +1 more source

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart [PDF]

, 1996
Plakoglobin (gamma-catenin), a member of the armadillo family of proteins, is a constituent of the cytoplasmic plaque of desmosomes as well as of other adhering cell junctions, and is involved in anchorage of cytoskeletal filaments to specific cadherins.
C Birchmeier, Behrend, M., Günthert, U., B Ledermann, F Vogel, M Behrend, Birchmeier, C., V Brinkmann, P Ruiz, U Günthert, Guenthert, U., Franke, W.W., C Thalhammer, Thalhammer, C., Vogel, F., Birchmeier, W., Ruiz, P., Ledermann, B., C Grund, Franke, W. W., Brinkmann, V., Grund, C., W Birchmeier, W W Franke   +23 more
core   +1 more source

Restricted expression of classic cadherins in the spinal cord of the chicken embryo

Frontiers in Neuroanatomy, 2014
Classic cadherins belong to the family of cadherin genes and play important roles in neurogenesis, neuron migration and axon growth. In the present study, we compared the expression patterns of 10 classic cadherins (Cdh2, Cdh4, Cdh6, Cdh7, Cdh8, Cdh9 ...
Juntang eLin, Juntang eLin, Congrui eWang, Congrui eWang, Christoph eRedies   +4 more
doaj   +1 more source

Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target

Frontiers in Oncology, 2019
Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and differentiation throughout life.
Weina Yu, Weina Yu, Weina Yu, Li Yang, Li Yang, Li Yang, Ting Li, Ting Li, Ting Li, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang   +12 more
doaj   +1 more source