Results 11 to 20 of about 30,352 (298)
Roads to Stat3 Paved with Cadherins
Cells, 2022 The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
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Cadherins as Matchmakers [PDF]
Neuron, 2011 Cadherins implement afferent-target matching in invertebrates, but proof for this concept in mammalian circuits has remained elusive. Two new studies in this issue of Neuron show that cadherin-6 mediates retinal ganglion cell target selection and that cadherin-9 promotes synapse specificity in the hippocampus.
Rebsam, Alexandra, Mason, Carol A.
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Evolutionary origin of type IV classical cadherins in arthropods
BMC Evolutionary Biology, 2017 Background Classical cadherins are a metazoan-specific family of homophilic cell-cell adhesion molecules that regulate morphogenesis. Type I and type IV cadherins in this family function at adherens junctions in the major epithelial tissues of ...
Mizuki Sasaki +2 more
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Expression of classic cadherins and δ-protocadherins in the developing ferret retina [PDF]
BMC Neuroscience, 2009 Background Cadherins are a superfamily of calcium-dependent adhesion molecules that play multiple roles in morphogenesis, including proliferation, migration, differentiation and cell-cell recognition.
Krishna-K K +2 more
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Cadherins and cardiovascular disease
Swiss Medical Weekly, 2009 Cardiovascular diseases encompass an enormous range of conditions arising through an equally diverse aetiology. The cadherin superfamily of cell surface adhesion molecules have long been recognised for their crucial roles in morphogenesis and controlled ...
TJ Resink, MB Joshi, E Kyriakakis
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EvoDevo, 2023 Background Cadherins are calcium-dependent transmembrane cell–cell adhesion proteins that are essential for metazoan development. They consist of three subfamilies: classical cadherins, which bind catenin, protocadherins, which contain 6–7 calcium ...
Macie M. Chess +3 more
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Autoregulation of E-cadherin expression by cadherin–cadherin interactions [PDF]
The Journal of Cell Biology, 2003 Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin–β-catenin complex. We investigated the molecular basis of this regulation,
Conacci-Sorrell, Maralice +5 more
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E-Cadherin Is Expressed in Epithelial Cells of the Choroid Plexus in Human and Mouse Brains
Current Issues in Molecular Biology, 2023 Evidence showing the functional significance of the choroid plexus is accumulating. Epithelial cells with tight and adherens junctions of the choroid plexus play important roles in cerebrospinal fluid production and circadian rhythm formation.
Genta Takebayashi +10 more
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Journal of Cell Science, 2008 The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor
Margaret J, Wheelock +4 more
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Cadherins can dimerize via asymmetric interactions [PDF]
, 2022 Cadherins are essential cell-cell adhesion proteins that interact in two distinct conformations: X-dimers and strand-swap dimers. Both X-dimers and strand-swap dimers are thought to exclusively rely on symmetric sets of interactions between key amino ...
Sanjeevi Sivasankar +5 more
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