Results 11 to 20 of about 28,625 (255)

Cadherins can dimerize via asymmetric interactions [PDF]

, 2022
Cadherins are essential cell-cell adhesion proteins that interact in two distinct conformations: X-dimers and strand-swap dimers. Both X-dimers and strand-swap dimers are thought to exclusively rely on symmetric sets of interactions between key amino ...
Sanjeevi Sivasankar, Sivasankar, Sanjeevi, Priest, Andrew Vae, Koirala, Ramesh, Ramesh Koirala, Andrew Vae Priest   +5 more
core   +1 more source

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart [PDF]

, 1996
Plakoglobin (gamma-catenin), a member of the armadillo family of proteins, is a constituent of the cytoplasmic plaque of desmosomes as well as of other adhering cell junctions, and is involved in anchorage of cytoskeletal filaments to specific cadherins.
C Birchmeier, Behrend, M., Günthert, U., B Ledermann, F Vogel, M Behrend, Birchmeier, C., V Brinkmann, P Ruiz, U Günthert, Guenthert, U., Franke, W.W., C Thalhammer, Thalhammer, C., Vogel, F., Birchmeier, W., Ruiz, P., Ledermann, B., C Grund, Franke, W. W., Brinkmann, V., Grund, C., W Birchmeier, W W Franke   +23 more
core   +1 more source

Roads to Stat3 Paved with Cadherins

, 2022
The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Raptis, Leda, Hanad Adan, Daniel, Juliet, Adan, Hanad, Juliet Daniel, Leda Raptis   +5 more
core   +1 more source

Three Functions of Cadherins in Cell Adhesion [PDF]

, 2013
Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis.
Maître, Jean-Léon, Maître, Jean-Léon ; https://orcid.org/, Heisenberg, Carl-Philipp, Heisenberg, Carl-Philipp J ; https://orcid.org/   +3 more
core   +1 more source

Cadherins as regulators of neuronal polarity

, 2015
A compelling amount of data is accumulating about the polyphonic role of neuronal cadherins during brain development throughout all developmental stages, starting from the involvement of cadherins in the organization of neurulation up to synapse ...
Fornasiero, Eugenio F., Dotti, Carlos, Gärtner, Annette, Gätner, Annette, Dotti, Carlos G.   +4 more
core   +2 more sources

Microtubules and cadherins: a neglected partnership

, 2009
Classical cadherins are fundamental determinants of tissue organization both in health and disease. It has long been recognized that cadherins function in close cooperation with the cytoskeleton, particularly with actin.
Akhmanova, A, Stehbens, SJ, Stehbens, S. J., Yap, AS, Yap, A. S., Stehbens, Samantha, J., Akhmanova, Anna, Yapp, Alpha S.   +7 more
core   +1 more source

Cadherins in the human placenta : epithelial-mesenchymal transition (EMT) and placental development

, 2010
Colonisation of the maternal uterine wall by the trophoblast involves a series of alterations in the behaviour and morphology of trophoblast cells. Villous cytotrophoblast cells change from a well-organised coherently layered phenotype to one that is ...
R. Wafai, M.I. Kokkinos, D.F. Newgreen, Kokkinos, M.I., Wafai, R., Newgreen, D.F., P. Murthi, Murthi, P., Thompson, E.W., E.W. Thompson   +9 more
core   +1 more source

Evolution of cadherins and associated catenins

, 2016
During more than 600 Ma of multicellular animal evolution, the cadherin superfamily has become strikingly diverse, both structurally and functionally. Cadherins are typically transmembrane proteins with an ectodomain comprising so-called cadherin repeats.
Frans van Roy, Ismail Sahin Gul, Van Roy, Frans, Paco Hulpiau, Gül, Ismail Sahin, Hulpiau, Paco   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cadherins and synaptic plasticity

, 2008
Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic ...
Tai, C., Schuman, E., Kim, Sally A., Kim, S., Tai, Chin-Yin, Schuman, Erin M.   +5 more
core   +1 more source