Results 91 to 100 of about 30,352 (298)

Cadherins and epithelial-to-mesenchymal transition

, 2013
Epithelial–mesenchymal transition (EMT) is a process whereby epithelial cells are transcriptionally reprogrammed, resulting in decreased adhesion and enhanced migration or invasion.
Alexander Gheldof, Berx, Geert, Gheldof, Alexander, Geert Berx   +3 more
core   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Phrenic-specific transcriptional programs shape respiratory motor output

eLife, 2020
The precise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, the molecular mechanisms that give rise to specific patterns of MN activity are largely unknown.
Alicia N Vagnozzi, Kiran Garg, Carola Dewitz, Matthew T Moore, Jared M Cregg, Lucie Jeannotte, Niccolò Zampieri, Lynn T Landmesser, Polyxeni Philippidou   +8 more
doaj   +1 more source

Ancestral roles of atypical cadherins in planar cell polarity [PDF]

, 2020
Fat, Fat-like, and Dachsous family cadherins are giant proteins that regulate planar cell polarity (PCP) and cell adhesion in bilaterians. Their evolutionary origin can be traced back to prebilaterian species, but their ancestral function(s) are unknown.
Steele, Robert E, McNeill, Helen, Steele, Robert E., Klimovich, Alexander, Pearson, Bret J, Pearson, Bret J., Brooun, Maria, Bashkurov, Mikhail   +7 more
core   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Circulating cell adhesion molecules in systemic sclerosis: a systematic review and meta-analysis

Frontiers in Immunology
IntroductionPatients with systemic sclerosis (SSc) have an increased risk of endothelial dysfunction, atherosclerosis, and cardiovascular events compared to the general population.
Arduino A. Mangoni, Arduino A. Mangoni, Angelo Zinellu   +2 more
doaj   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells

Stem Cell Reports, 2017
Calreticulin, a multifunctional endoplasmic reticulum resident protein, is required for TGF-β-induced epithelial-to-mesenchymal transition (EMT) and subsequent cardiomyogenesis. Using embryoid bodies (EBs) derived from calreticulin-null and wild-type (WT)
Fereshteh Karimzadeh, Michal Opas
doaj   +1 more source

Doctor of Philosophy [PDF]

, 2017
dissertationSingle neurons often receive synapses with distinct properties. However, the molecules regulating these distinct properties remain largely unknown. This dissertation focuses on deciphering such molecules using the mammalian hippocampus as the
Basu, Raunak
core  

Transcriptional regulation of cadherins during development and carcinogenesis [PDF]

, 2013
The cadherin superfamily of Ca2+-dependent homophilic adhesion molecules plays a critical role in regulating cell-to-cell interactions. During development, the expression of different cadherins is highly dynamic, since they are associated with the ...
Cano, Amparo, Peinado, Héctor, Portillo, Francisco   +2 more
core   +1 more source