Results 101 to 110 of about 30,352 (298)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Evaluation of CDH1;RUNX3 Expression in Cancerous and Normal Tissue of Patients With Gastric Cancer

پزشکی بالینی ابن سینا, 2017
Introduction: Gastric cancer is a multifactorial disease and the fourth most common cancer in the world and the second cause of death from cancer. This study was designed and performed to investigate CDH1 and RUNX3 genes expression in healthy and tumor ...
M Einolghozati, MH Sanati, H Efftpanah, N Shabab, M Saidijam   +4 more
doaj  

Cadherins in the Developing Central Nervous System: An Adhesive Code for Segmental and Functional Subdivisions [PDF]

, 1996
In this review, we describe general features of the expression of cadherins in the developing central nervous system (CNS) of vertebrates. In the early neuroepithelium, the expression of several cadherins is restricted to specific regions corresponding ...
Redies, Christoph, Takeichi, Masatoshi, Masatoshi Takeichi, Christoph Redies   +3 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation [PDF]

, 2018
Classical cadherins, a set of ~20 related recognition and signaling molecules, have been implicated in many aspects of neural development, including the formation and remodeling of synapses.
Yamagata, Masahito, Sanes, Joshua, Masahito Yamagata, Joshua R. Sanes, Xin Duan, Duan, Xin   +5 more
core   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Las cadherinas en el diagnostico histopatológico y pronostico del carcinoma de células renales The cadherins in the histopathology diagnosis and prognosis of renal cell carcinoma

Revista Habanera de Ciencias Médicas, 2011
El carcinoma de células renales es el cáncer renal más común en el adulto. Se describen 5 tipos histológicos principales, que, en general, muestran al microscopio óptico características que permiten diagnosticarlos.
Anay Marquetti Hernández, Reinhard Gessner   +1 more
doaj  

Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

eLife
The atypical cadherins Fat and Dachsous (Ds) signal through the Hippo pathway to regulate growth of numerous organs, including the Drosophila wing. Here, we find that Ds-Fat signaling tunes a unique feature of cell proliferation found to control the rate
Andrew Liu, Jessica O’Connell, Farley Wall, Richard W Carthew   +3 more
doaj   +1 more source

Role of Cadherins in Cancer—A Review

, 2020
Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis.
Bożena Dworecka-Kaszak, Zuzanna Niewiadomska, Felix Ngosa Toka, Olga Witkowska-Piłaszewicz, Piotr Jurka, Ilona Kaszak   +5 more
core   +1 more source