Results 111 to 120 of about 44,600 (299)

Fluid Forces Control Structural Remodeling of Blind‐Ended Lymphatic Microvessels

Advanced Healthcare Materials, EarlyView.
Using innovative microfluidic biofabrication with fluid mechanical insights, we recapitulated the blind‐ended microanatomy and physiological drainage properties of capillary lymphatics. Our results reveal the interrelationship between intra‐ and extraluminal regions of lymphatic vessels due to flow‐induced sprouting and morphological changes that ...
Jacob C. Holter, Shashwat S. Agarwal, Joseph W. Tinapple, Joseph M. Barlage, Travis H. Jones, Jonathan W. Song   +5 more
wiley   +1 more source

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source

High‐Throughput Generation of Tumor Spheroids via Droplet Microfluidics for siRNA‐Loaded Nanomedicine Assessment

Advanced Healthcare Materials, EarlyView.
A droplet microfluidic platform is employed to enable high‐throughput, uniform tumor spheroid generation for evaluating siRNA‐loaded nanomedicines at the protein level. As a proof of concept, breast (MCF‐7) and brain (U87 MG) cancer cell lines are investigated using this platform, revealing penetration profiles and therapeutic responses between the two
Ling Liu, Guoying Wang, Yang Zhang, Bingyang Shi, Ming Li   +4 more
wiley   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Proteolytic cleavage of cadherins: Functional role of the cleaved extracellular and cytoplasmic domains [PDF]

, 2006
Dynamic regulation of cadherin mediated cell-cell adhesion is crucial for morphogenesis and tissue homeostasis. Cadherin adhesive function can be regulated by distinct proteolytic cleavage events, resulting in release of either the ectodomain or ...
Billion, Karla
core  

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Possible origins of macroscopic left-right asymmetry in organisms

, 2012
I consider the microscopic mechanisms by which a particular left-right (L/R) asymmetry is generated at the organism level from the microscopic handedness of cytoskeletal molecules.
A. Tamada, A. Varma, A. Vilfan, A.M. Heacock, A.R. Palmer, C. Ambrose, C. Arrieumerlou, C. McManus, C. Pohl, C.H. Wiggins, C.L. Henley, C.R. Cowan, C.S. Peskin, C.W. Wolgemuth, Christopher L. Henley, D. Vavylonis, D.S. Adams, D.W. Ehrhardt, E. Ben-Jacob, E. Ben-Jacob, E. Kawamura, E.C. Eren, E.C. Eren, E.E. Deinum, F. Ziebert, F.C. Frank, G. Salbreux, G.M. Grason, G.O. Wasteneys, H. Hamada, H.F. Romijn, I. Mabuchi, J. Chan, J. Chan, J. Cooke, J. Gore, J. Hagmann, J. Salje, J. Xu, J.A. Åström, J.F. Allard, J.F. Allard, J.F. Beausang, J.H.E. Cartwright, K. Taniguchi, L.F. Jones, L.Q. Wan, M. Levin, M. Levin, M. Levin, M. Mayer, M.E. Halpern, M.L. Manning, M.P. Wold, M.V. Danilchik, M.V. Thompson, M.Y. Ali, N. Hirokawa, N. Morone, N.A. Brown, N.H. Mendelson, N.H. Mendelson, P. Spéder, P. Spéder, R. Dixit, R. Kawamura, R. Kuroda, R.D. Kamien, R.D. Preston, R.J. Hawkins, R.J. Poole, R.M. Figge, S. Aw, S. Hozumi, S. Nonaka, S. Nonaka, S. Thitamadee, S. Wang, S.H. Tindemans, S.L. Shaw, S.S. Andrews, T. Hashimoto, T. Ishida, T. Kamasaki, T. Lionnet, T. Nishizaka, T. Okumura, T. Sun, T.-H. Chuan, V.A. Avertisov, V.A. Baulin, W. Lauga, W.B. Wood, W.B. Wood, W.B. Wood, W.R. DiLuzio, X.-Q. Shi, Y. Nakadera, Y. Shibazaki, Y. Wu, Y.B. Malashichev   +100 more
core   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Unconventional Cadherin Localization in Honey Bee Gonads Revealed Through Domain-Specific Apis mellifera E- and N-Cadherin Antibodies Indicates Alternative Functions

Insects, 2012
As key factors in intercellular adhesion processes, cadherins play important roles in a plethora of developmental processes, including gametogenesis. In a previous study on cadherin localization in the gonads of honey bees, performed with heterologous ...
Klaus Hartfelder, Mônica M. Florecki
doaj   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source