Results 261 to 270 of about 18,651,759 (343)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Retraction Note: RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma. [PDF]

BMC Cancer
Zhang Y, Sun L, Gao X, Guo A, Diao Y, Zhao Y.   +5 more
europepmc   +1 more source

Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma.

International Journal of Oncology, 2015
Yan-sheng Wu, Li Zhang, Lun Zhang, Yang Wang, Hui Li, X. Ren, F. Wei, Wenwen Yu, Ting Liu, Xudong Wang, Xuan Zhou, Jinpu Yu, X. Hao   +12 more
semanticscholar   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Dysadherin expression in prostatic adenocarcinoma and its relationship with E-cadherin and β-catenin. [PDF]

Future Sci OA
Limani R, Kondirolli L, Blakaj Gashi B, Ulamec M, Krušlin B.   +4 more
europepmc   +1 more source

Mechanical strain induces E-cadherin–dependent Yap1 and β-catenin activation to drive cell cycle entry

Science, 2015
Yusuke Sekine, A. Zyryanova, Ana Crespillo-Casado, Peter M. Fischer, H. Harding   +4 more
semanticscholar   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Expression of E-CADHERIN and miR-200b in Different Forms of Endometriosis. [PDF]

Biomedicines
Ntzeros K, Voros C, Mavrogianni D, Kathopoulis N, Kypriotis K, Varthaliti A, Darlas M, Douligeris A, Protopapas A.   +8 more
europepmc   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

TMBIM1 promotes epithelial mesenchymal transition by accelerating autophagic degradation of E-cadherin in glioblastoma. [PDF]

Sci Rep
Gao L, Liu J, Li Y, Yang J, Cai J, Wang L, Ye Z, Tong S, Deng G, Chen Q, Cai Q.   +10 more
europepmc   +1 more source