Results 271 to 280 of about 18,651,759 (343)

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

E-cadherin endocytosis promotes non-canonical EGFR:STAT signalling to induce cell death and inhibit heterochromatinisation. [PDF]

PLoS Genet
Ramirez Moreno M, Quinton A, Jacobsen E, Stempor PA, Zeidler MP, Bulgakova NA.   +5 more
europepmc   +1 more source

Decreased E-cadherin expression is associated with poor prognosis in patients with Barrett's adenocarcinomas

, 1995
K K Krishnadath, Hugo W. Tilanus, M. van Blankenstein, Fred T. Bosman   +3 more
openalex   +1 more source

Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa ...
Yeong‐In Jo, Jee Won Moon, Joo‐Hoo Park, Hwa Eun Yang, Subin Cho, Hyeongguk Son, Hyun‐Woo Yang, Il‐Ho Park   +7 more
wiley   +1 more source

E-cadherin expression in the tongue epithelium of streptozotocin-induced diabetic rats: an exploratory study. [PDF]

Acta Odontol Scand
Kaabi HH, Alsoghier AM, Alredah IA, Alqahtani RM, Alsanie IS, Balto HA.   +5 more
europepmc   +1 more source

Soluble E-Cadherin Facilitates Pre-Metastatic Niche Hyperpermeability Via Rac2

Jingwen Zhou, 泉 長友, Jing Kong
openalex   +1 more source

Clinical significance of Twist, E-cadherin, and N-cadherin protein expression in endometrioid adenocarcinoma

, 2017
Xin-Ping Xie, Xiu Zheng, Jinhua Wang, Lihong Chen   +3 more
openalex   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review. [PDF]

Obstet Gynecol Sci
Adamyan L, Pivazyan L, Obosyan L, Kurbatova K, Platonova E, Mailova K, Stepanian A.   +6 more
europepmc   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source