Results 311 to 320 of about 18,651,759 (343)

E-cadherin expression in human melanoma

Melanoma Research, 1996
Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tumour progression.
Danen, E H, de Vries, T J, Morandini, R, Ghanem, Ghanem Elias, Ruiter, D J, van Muijen, G N   +5 more
openaire   +2 more sources

E-Cadherin Germline Mutations

2013
Hereditary Diffuse Gastric Cancer is the only gastric cancer syndrome with a proven inherited defect. So far, a single gene has been found altered in this context – CDH1 – the E-cadherin encoding gene. Other E-cadherin-associated hereditary or inheritable disorders have been identified, encompassing Hereditary Diffuse Gastric Cancer families with or ...
Joana Carvalho, Hugo Pinheiro, Carla Oliveira   +2 more
openaire   +1 more source

Hypermethylation of E-cadherin in leukemia

Blood, 2000
E-cadherin gene is often termed a “metastasis suppressor” gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignancies is only now being recognized.
J R, Melki, P C, Vincent, R D, Brown, S J, Clark   +3 more
openaire   +2 more sources

E‐cadherin expression in canine cutaneous histiocytoma

Veterinary Record, 2008
Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen‐presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E‐cadherin.
S J, Baines, E F, McInnes, I, McConnell
openaire   +2 more sources

Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia

American Journal of Physiology-Renal Physiology, 2000
Ischemic epithelial cells are characterized by disruption of intercellular junctions and loss of apical-basolateral protein polarity, which are normally dependent on the integrity of the adherens junction (AJ). Biochemical analysis of both whole ischemic kidneys and ATP-depleted Madin-Darby canine kidney (MDCK) cells demonstrated a striking loss of E ...
K T, Bush, T, Tsukamoto, S K, Nigam
openaire   +2 more sources

DDR1 regulates the stabilization of cell surface E‐cadherin and E‐cadherin‐mediated cell aggregation

Journal of Cellular Physiology, 2010
AbstractThe stabilization of cell surface E‐cadherin is important for the maintenance of apical junction complexes and epithelial polarity. Previously, we reported that discoidin domain receptor 1 (DDR1) forms a complex with E‐cadherin at adhesive contacts; however, the regulatory role of DDR1 in the stabilization of cell surface E‐cadherin and E ...
Rajalakshmanan, Eswaramoorthy, Chih-Kuang, Wang, Wen-Cheng, Chen, Ming-Jer, Tang, Mei-Ling, Ho, Chi-Ching, Hwang, Hui-Min, Wang, Chau-Zen, Wang   +7 more
openaire   +2 more sources

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling

Nature Cell Biology, 2021
Xinya Gao, Xin Xia, Fanying Li, Maolei Zhang, Huangkai Zhou, Xujia Wu, Jian Zhong, Zheng Zhao, Kun Zhao, Dawei Liu, Feizhe Xiao, Qiang Xu, Tao Jiang, Bo Li, Shi-Yuan Cheng, Nu Zhang   +15 more
semanticscholar   +1 more source

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Nature Cell Biology, 2000
E. Batlle, E. Sancho, C. Francı́, David Domı́nguez, M. Monfar, J. Baulida, A. G. Herreros   +6 more
semanticscholar   +1 more source

E-cadherin

AfCS-Nature Molecule Pages, 2010
Karl-Friedrich Becker, Birgit Luber
openaire   +1 more source

Mechanisms of E-cadherin mechanotransduction

2018
<p>Cells experience force throughout their lifetimes. Cells sense force via adhesion receptors, such as the cadherins, which anchor cells to neighboring cells, and integrins, which tether cells to the underlying matrix. Both adhesion receptors respond to force by activating signaling pathways inside the cell.
Jennifer McQuown Bays, Kris DeMali, Dan Weeks, Todd Washington, Eric Taylor, Jon Houtman, Sheila Baker   +6 more
openaire   +1 more source