Results 11 to 20 of about 21,996,780 (301)

Efecto del reprensado en las propiedades mecánicas de guías de válvulas fabricadas por pulvimetalurgia

open access: yesRevista de Metalurgia, 2017
Se determinaron la dureza, pérdida de masa y coeficiente de fricción, de guías de válvulas para motores de combustión interna fabricadas en latón por proceso de pulvimetalurgia, con el objetivo de conocer si cumplen con las exigencias que requiere un ...
Andrés Rodríguez-Spitia   +4 more
doaj   +1 more source

Editorial [PDF]

open access: yesEntre Ciencia e Ingeniería, 2014
Breve resumen de los contenidos científicos que hay en la revistas de El Salvador Ciencia y ...
revista Entre ciencia e ingeniería
doaj   +2 more sources

Editorial [PDF]

open access: yesEntre Ciencia e Ingeniería, 2007
El establecimiento de la Política Nacional de Ciencia Tecnología e Innovación, se oficializó el 8 de diciembre de 2006, y consiste de un conjunto de acciones institucionales e individuales orientadas a promover y facilitar el desarrollo, la asimilación y
Revista Entre Ciencia e Ingeniería
doaj   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Comportamiento a desgaste de recubrimientos de material compuesto de matriz de aluminio fabricados por proyección térmica

open access: yesRevista de Metalurgia, 2007
En este trabajo se ha evaluado el comportamiento a desgaste de recubrimientos de material compuesto reforzado con un 20 % de partículas de SiC fabricados por proyección térmica con llama oxiacetilénica.
M. Campo   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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