Results 81 to 90 of about 99,397 (256)

A look at market and patterns of the use of electronic cigarettes in Poland: current and future risks for tobacco control

Tobacco Prevention and Cessation, 2019
In the past 10 years, a sharp increase in sale of e-cigarettes is observed on Polish tobacco market. Between 2008 and 2011, when sale of e-cigarettes reached a peak, the market expanded almost 8 times.
Krzysztof Przewoźniak
doaj   +1 more source

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases—An update

British Journal of Clinical Pharmacology, EarlyView.
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel, Adeline Benis, Philippe Bonniaud, Jean‐Luc Faillie, Aurélie Grandvuillemin   +4 more
wiley   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

ACKR1/Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Clozapine is licenced for treatment‐resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis.
Stephen Murtough, Oriella Stellakis, Daisy Mills, Blanca Bjourson, Vicky Chaplin, Dharmisha Chauhan, Bev Chipp, Marius Cotic, Jana de Villiers, Olubanké Dzahini, Frances Elmslie, Katie Evans, Shreyans Gandhi, Dyfrig A. Hughes, Huajie Jin, Daniele Panconesi, Anna Skowronska, Sanjay M. Sisodiya, Ed Silva, Vicky Stinton, Sara Stuart‐Smith, Sarah Tarrant, David Taylor, Lauren Varney, James T. R. Walters, Michelle Wood, Jessica Woodley, Cinzia Dello Russo, Munir Pirmohamed, Elvira Bramon   +29 more
wiley   +1 more source

Gender differences in preferences, gateway effects, and potential motivations among e-cigarette users in China

Frontiers in Public Health
ObjectiveA cross-sectional survey was conducted to investigate the differences in preferences, gateway effects, and potential motivations for e-cigarette use among different genders of e-cigarette users in China, thereby providing ideas for the ...
Wei Ji, Liyong Shi, Liyong Shi, Xinjun Lin, Zhiqiang Ji, Zhihuang Zhao, Yanping Chen, Pengxiang Huang, Xiali Wang, Xiaofang Dai, Jing Cheng, Lujun Guo, Diwei Wu, Yibiao Chen, Zhangcai Wu, Xiaoyang Chen, Xiaoyang Chen   +16 more
doaj   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Comparative assessment of respiratory, hematological and inflammatory profiles of long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia

Tobacco Induced Diseases
Introduction Globally, over 1 billion people smoke, resulting in approximately 8 million deaths each year. Although the health risks associated with traditional cigarettes are extensively documented, there is an increasing need to evaluate the long-term ...
Mazen M. Homoud, Rowaida Qoutah, Gokul Krishna, Noran Harbli, Layan Saaty, Afrah Obaidan, Abdulrahman Alkhathami, Noran Jamil, Tala Μ. Alkayyat, Maryam Alsughayyir, Nada Gubari, Saleh Alkhathami, Ali Alqarni, Omar Alqurashi, Khalid Assiri, Khalid Saeed Alwadeai, Wafaa Abdulrahman, Husam Alahmadi, Ayedh Alahmari   +18 more
doaj   +1 more source

Awareness, current use of electronic cigarettes and associated smoking factors in Zhejiang Chinese adolescents.

PLoS ONE, 2019
OBJECTIVES:The present study aims at examining the prevalence of awareness and current use of electronic cigarettes (e-cigarettes) among middle and high school students from Zhejiang, China.
Meng Wang, Ru-Ying Hu, Jin Pan, Hao Wang, Min Yu, Kai-Xu Xie, Wei-Wei Gong   +6 more
doaj   +1 more source

The Dangerous Flavors of E-Cigarettes

New England Journal of Medicine, 2019
Nicotine is amazingly addictive. About 20 years ago, researchers in a nearby laboratory were studying the effects of cigarette smoke on lung function in mice. To expose a mouse to cigarette smoke, the mouse is placed in a plastic tube, head out. The tube is positioned in a stream of smoke, which the mouse then breathes. On the day of the first exposure,
Jeffrey M, Drazen, Stephen, Morrissey, Edward W, Campion   +2 more
openaire   +2 more sources

Lowering salivary pH with sugar‐containing gum augments salivary nitrite production and blood pressure reduction with dietary nitrate (beetroot juice)

British Journal of Clinical Pharmacology, EarlyView.
Acutely lowering salivary pH (with sugar‐containing acidic gum vs. sugar‐free gum) augments salivary nitrate reduction to nitrite, plasma nitrite concentration, and blood pressure lowering with dietary nitrate. Modifying salivary pH reveals a mechanism by which the nitrate‐nitrite‐NO pathway may be upregulated/inhibited, with potential for other ...
Andrew J. Webb, Harriet Clift, Callum Hill, Nur Mousa, Navanithan Arun Jayaraj, Jasmine Quraishi, Charlotte E. Mills, Kevin O'Gallagher   +7 more
wiley   +1 more source