Results 51 to 60 of about 22,904 (279)

Proxy of democracy? : metaphors of connection as arguments against representation [PDF]

, 2012
This paper aims to assess the arguments that claim representative democracy may be enhanced or replaced by an updated electronic version. Focusing on the dimension of elections and electioneering as the core mechanism of representative democracy I will ...
Cuono, Massimo
core  

REGIONAL KNOWLEDGE MANAGEMENT FOR THE SUSTAINABLE DEVELOPMENT [PDF]

, 1994
The article intends to present the achievements of a research Romanian project Knowledge management architecture in environmental, social and economic areas,designed to support the sustainable regional development strategy .
Mihaela Muresan
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Updating democracy studies: outline of a research program [PDF]

, 2012
Technologies carry politics since they embed values. It is therefore surprising that mainstream political and legal theory have taken the issue so lightly.
Mindus, Patricia
core  

Online engagement from the grassroots: Reflecting on over a decade of ePetitioning experience in Europe and the UK [PDF]

, 2012
The official published verison of this chapter can be accessed from the link below - Copyright @ 2012 SpringerExtensive debate on Internet and formal politics has concentrated on whether authorities should focus their efforts on high-volume activities ...
Elliman, T, Panagiotopoulos, P
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A business model perspective for ICTs in public engagement [PDF]

, 2012
This is the post-print version of the Article. The official published article can be accessed from the link below - Copyright @ 2012 ElsevierPublic institutions, in their efforts to promote meaningful citizen engagement, are increasingly looking at the ...
Al-Debei, Al-Debei, Andersen, Anduiza, Avgerou, Bingham, Bouwman, Callanan, Carman, Chadwick, Chan, Chee, Chesbrough, Cordella, Currie, Dawes, Dubé, Dutton, Dutton, Fedorowicz, Flak, Fountain, Gregor, Gronlund, Guy Fitzgerald, Heeks, Irani, Jaeger, Janssen, Janssen, Janssen, Kim, Kumar, Local Democracy, Economic Development and Construction Act, Local E-Democracy National Project, Lowndes, Macintosh, Macintosh, Macintosh, Macintosh, Magretta, Meijer, Miller, Miller, Mutaz M. Al-Debei, Myers, Norris, Nyholm, Panagiotis Panagiotopoulos, Panagiotopoulos, Peixoto, Rose, Rose, Saebo, Shafer, Timmers, Tomkova, Tony Elliman, West, Whyte, Yildiz, Yin   +61 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Impact of Information and Communication Technologies on Democratic Processes and Citizen Participation

Societies
Background: This systematic review will address the influence of Information and Communication Technologies (ICTs) on democratic processes and citizens’ participation, which is enabled by such tools as social media, e-voting systems, e-government ...
George Asimakopoulos, Hera Antonopoulou, Konstantinos Giotopoulos, Constantinos Halkiopoulos   +3 more
doaj   +1 more source

From Dahl to O’Leary: 36 Years of the “Yale School of Democratic Reform”

Journal of Deliberative Democracy, 2007
A review of Kevin O’Leary’s book, Saving Democracy: A Plan for Real Representation in America.
J. H. Snider
doaj   +2 more sources