Results 81 to 90 of about 7,111,544 (260)

Presentación Dossier "Belgrano y su tiempo"

open access: yesInvestigaciones y Ensayos, 2021
En ocasión de conmemorarse los doscientos cincuenta años del nacimiento de Manuel Belgrano y el bicentenario de su fallecimiento, la Academia Nacional de la Historia convocó a especialistas e investigadores a un magno congreso para celebrar al prócer de ...
Miguel Ángel (h) De Marco   +1 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

La construcción de la unanimidad en los pueblos rurales bonaerenses. Reflexiones a partir de algunos episodios electorales (1830-1835)

open access: yesInvestigaciones y Ensayos, 2021
Este artículo examina los mecanismos y prácticas que permitieron la construcción de la unanimidad electoral en los pueblos rurales del Estado de Buenos Aires durante la primera mitad del siglo XIX. Nos interesa visualizar algunos aspectos que colaboraron
Vicente Agustín Galimberti
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

“La vida al día”: modernización periodística y noticias policiales en la prensa anarquista y socialista de Buenos Aires a comienzos del siglo XX

open access: yesInvestigaciones y Ensayos, 2021
En este artículo analizamos la presencia de noticias policiales en La Protesta y La Vanguardia, principales periódicos del anarquismo y socialismo de la ciudad de Buenos Aires en la primera década del siglo XX.
Martín Albornoz, Juan Buonuome
doaj  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

El general en el banquillo. Guerra y política en los juicios por las derrotas en el Paraguay y el Alto Perú

open access: yesInvestigaciones y Ensayos, 2021
Este trabajo estudia los procesos judiciales a los que fue sometido Manuel Belgrano luego del fracaso de la expedición al Paraguay en 1811 y de las derrotas militares sufridas en el Alto Perú en 1813.
Irina Polastrelli
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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