Results 171 to 180 of about 4,769,695 (288)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Role of e-health in addressing sarcopenic obesity: a scoping review protocol. [PDF]

BMJ Open
Nørtoft M, Nørtoft M, Graungaard S, Iheme GO, Karagianni V, Bereczky R, Ellegaard L, Boström AM.   +7 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Improving patient care and safety in the community through technology

International Journal of Integrated Care, 2013
Cathy Szabo
doaj   +1 more source

E-health intervention in pregnant women exposed to intimate partner violence (eIPV): Results of a pilot randomised controlled trial. [PDF]

Contemp Clin Trials Commun
Zapata-Calvente AL, Bueno Cavanillas A, Andreasen K, Linde DS, Rasch V, Khan KS, Martín-de-Las-Heras S.   +6 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Proceedings of the 3rd edition of the International e-Health Forum 2024. [PDF]

BMC Proc
europepmc   +1 more source

Scaling holistic e-health solutions in cancer care using a qualitative realist framework. [PDF]

Front Public Health
Melhem SJ, Nabhani-Gebara S, Bulatova N, Alabbadi I, Almomani H, Mousa R, Almousa A, AlRashdan Y, Nimri O, Kayyali R.   +9 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Correction: Proceedings of the 3rd edition of the International e-Health Forum 2025. [PDF]

BMC Proc
europepmc   +1 more source