Results 171 to 180 of about 32,759,036 (278)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Genetic Correlates of Treatment Utilization for Alcohol Use Disorder: A Family-Based and Polygenic Investigation. [PDF]

Alcohol Clin Exp Res (Hoboken)
Spychala KM, Garasky CE, Clapp Sullivan ML, Johnson EC, Kutzner J, Lai D, Jinwala Z, Miller AP, Dick DM, Rabinowitz JA, Kuo SI, Nurnberger J, Plawecki MH, Pandey AK, Chan G, Dash GF, Kinreich S, Schuckit M, Dong F, Hesselbrock V, Porjesz B, Bucholz KK, McCutcheon VV, Bogdan R, Agrawal A.   +24 more
europepmc   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Body mass index and type 2 diabetes liability in osteomyelitis and cellulitis: A cross-biobank Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu F, Luo K, Liu H.
europepmc   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Mendelian randomization analysis of the causal relationship between allergic rhinitis and depression and underlying mediation mechanisms. [PDF]

World Allergy Organ J
Zhang S, Wang R, Weng J, Li M, Shi M, Wei J, Ye L, Huang X, Huang W, Qu S.   +9 more
europepmc   +1 more source

Are pregnancy‐ and lactation‐related eligibility criteria in cardiovascular clinical trials underpinned by drug safety data?

British Journal of Clinical Pharmacology, EarlyView.
Aim To quantify the prevalence of pregnancy‐, lactation‐ and reproductive potential‐related eligibility criteria in cardiovascular clinical trials and to evaluate whether they are supported by drug‐specific safety data. Methods We analysed randomized phase 3 and phase 4 cardiovascular clinical trials registered on ClinicalTrials.gov between 1 January ...
Jera Gurakuqi, Mira G. P. Zuidgeest, Susan van Dijk, Mariana Cajamarca Parra, Ewout W. Steyerberg, Ruurd J. A. Kuiper, Sanne A. E. Peters   +6 more
wiley   +1 more source

Racial gaps without racism: How English universities frame inequality in access and participation plans

British Educational Research Journal, EarlyView.
Abstract Racial inequalities are pervasive in higher education despite concerted efforts to redress issues of access, progression and continuation. Little attention has been paid to how universities themselves construct race within their policy texts.
Benjamin Hart, Mirna Šumatić
wiley   +1 more source

Association of Thyroid Autoimmunity With Age-Related Macular Degeneration in U.S. Adults. [PDF]

Transl Vis Sci Technol
Chen X, Zhang J, Wong TY, Huang L, Wang YX.   +4 more
europepmc   +1 more source

Educational philosophising in the Everyday: UK immigrant mothers navigating identity and praxis during COVID‐19

British Educational Research Journal, EarlyView.
Abstract Debates surrounding motherhood have long centred on women's roles as carers. Although motherhood is now more widely recognised within feminist scholarship, it often remains conceptually separate from identities associated with formal educational discourse.
Lavinia Kamphausen, Aliya Khalid, Nadia Uddin‐Talukder, Uzma Dayan   +3 more
wiley   +1 more source