Results 91 to 100 of about 1,182,951 (299)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Contribution à la modélisation des approches de coopération en e-maintenance.

, 2006
International audienceCe travail traite des problèmes liés à la modélisation de la coopération entre différents agents (experts) situés à diffé-rents endroits, pour aider à diagnostiquer et à réparer des défaillances, dans un contexte de e-maintenance ...
Chelbi, Anis, Radhouane Bennour, Mohamed, Zerhouni, Noureddine   +2 more
core   +1 more source

Index for asset value measure obtained from condition monitoring digitalized data interpretation. A railway asset management application [PDF]

, 2019
Hosted by the Johannes Kepler University, Linz, Austria. May 23-24, 2019The objective of any asset is to provide value to the organization, being the corner stone to get a highest possible economic benefit in a sustainable way. An effective asset value
Candón, Eduardo, Crespo Márquez, Adolfo, Fuente, Antonio de la, González, Pablo, Guillén López, Antonio Jesús, Martínez-Galán, Pablo   +5 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

FabV/Triclosan Is an Antibiotic-Free and Cost-Effective Selection System for Efficient Maintenance of High and Medium-Copy Number Plasmids in Escherichia coli.

PLoS ONE, 2015
Antibiotic resistance genes and antibiotics are frequently used to maintain plasmid vectors in bacterial hosts such as Escherichia coli. Due to the risk of spread of antibiotic resistance, the regulatory authorities discourage the use of antibiotic ...
Syed A Ali, Yik Wei Chew
doaj   +1 more source

Exigências de energia para mantença e eficiência de utilização da energia metabolizável para mantença e ganho de peso de caprinos Moxotó Energy requirements for maintenance and net efficiency of metabolizable energy utilization for maintenance and weight gain of Moxotó kids

Revista Brasileira de Zootecnia, 2008
Objetivou-se avaliar as exigências líquidas de energia para mantença e as eficiências de utilização da energia metabolizável (EUEM) para mantença (km) e ganho de peso (kf).
Kaliandra Souza Alves, Francisco Fernando Ramos de Carvalho, Antonia Sherlânea Chaves Véras, Ângela Maria Vieira Batista, Geovergue Rodrigues de Medeiros, Valéria Louro Ribeiro, Alessandra Oliveira de Araújo   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Epidural Dexmedetomidine Reduces the Requirement of Propofol during Total Intravenous Anaesthesia and Improves Analgesia after Surgery in Patients undergoing Open Thoracic Surgery

Scientific Reports, 2017
The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery.
Xianzhang Zeng, Jingjing Jiang, Lingling Yang, Wengang Ding   +3 more
doaj   +1 more source