Results 131 to 140 of about 1,153,866 (283)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Virus Reduction by the Stanford Onsite Wastewater Treatment System [PDF]
, 1990 A field study to examine the Stanford Onsite Wastewater Treatment System\u27s ability to remove bacteriophage from wastewater was conducted. MS2 Coliphage was Injected Into the low pressure pipe (LPP) distribution system to achieve an Influent ...
Gross, Mark A.
core +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Conceptual design and integration of a space station resistojet propulsion assembly [PDF]
The resistojet propulsion module is designed as a simple, long life, low risk system offering operational flexibility to the space station program. It can dispose of a wide variety of typical space station waste fluids by using them as propellants for ...
Tacina, Robert R.
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Drives and benefits overview [PDF]
The major technology issues for an advanced orbital transfer vehicles (OTV) engine to be used in conjunction with a space based, reusable orbit transfer vehicle are discussed.
Mcintyre, S. D.
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Políticas públicas de financiamento da educação no Brasil
EccoS – Revista Científica, 2006 This article studies the main topics of the Brazilian education policies, especially the primary education financing. It is also commented the question of the public financing for Education, taking as base the Federal Constitution of 1988, the Lei de ...
João Cardoso Palma Filho
doaj
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source