Results 131 to 140 of about 23,402,107 (303)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Hypothesis-based concept assignment to support software maintenance [PDF]
, 2000 Software comprehension is one of the most expensive activities in software maintenance and many tools have been developed to help the maintainer reduce the time and cost of the task.
Gold, N E +2 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2008 proven difficult in the absence of design information [19]; maintainers often spend considerable energy trying to recover this design information before making changes [15].
Lditional Maintenance Has
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Majlesi Journal of Electrical EngineeringThe completely Electric Power System encompass three parts: Generation, Transmission, and Distribution that all require maintenance to better system reliability and energy efficiency.
Ahmad Norozpour Niazi +2 more
doaj
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Software maintenance: generating front ends for cross referencer tools [PDF]
, 1989 This thesis surveys the activities performed in software maintenance and identifies some of the software tools which can be utilised by the maintenance programmer.
Turver, Richard John
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Maintenance awareness in wireless sensor networks [PDF]
, 2004 In wireless sensor networks where deployment is expected to surpass the lifetime of batteries, a major part of the operation costs is expected to be consumed by maintenance costs.
Sreenan, Cormac J. +2 more
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